(2S,5R)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester CAS 1638744-26-9
| CAS No. | 1638744-26-9 |
| Molecular Formula | C18H28N2O2 |
| Molecular Weight | 304.43 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
(2S,5R)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (CAS 1638744-26-9) is a high-purity analytical reference standard with the molecular formula C18H28N2O2 and a molecular weight of 304.43 g/mol.
The molecular framework of (2S,5R)-4-Benzyl-2,5-dimethyl-piperazine-1-carboxylic acid tert-butyl ester (C18H28N2O2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H28N2O2 |
| Molecular Weight | 304.43 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 2 |
Recommended Standards
- Tert-butyl (1-benzyl-4-methylpiperidin-4-yl)carbamate (CAS 163271-07-6)
- tert-Butyl (4-benzylpiperidin-4-yl)methylcarbamate (CAS 1707602-65-0)
- tert-Butyl 4-(aminomethyl)-4-benzylpiperidine-1-carboxylate (CAS 1432296-90-6)
- tert-Butyl (1-benzylpiperidin-3-yl)(methyl)carbamate (CAS 172477-99-5)
- 1-(6-Amino-2-chlorophenyl)azepane (CAS 926215-35-2)
- 2-(Chloromethyl)quinolin-4(1h)-one (CAS 946712-03-4)
- 3-Cyclopropoxy-4-fluoropicolinonitrile (CAS 1243451-96-8)
- 2-[(4,5-Dimethyl-furan-2-carbonyl)-amino]-benzoic acid (CAS 412938-26-2)
- 4-Amino-6-ethylquinoline-3-carboxylic acid (CAS 1242260-53-2)
- 2-(2-Iminothiazolidin-3-yl)-1-phenylethan-1-one Hydrobromide (CAS 4335-26-6)
- 4-Amino-3-(2-ethylphenyl)butanoic acid (CAS 1498679-12-1)
- 1-(2-Methylpropyl)cyclopentane-1-carbonitrile (CAS 1384583-59-8)
- (5-(Aminomethyl)pyridin-2-yl)dimethylphosphine oxide (CAS 2613385-70-7)
- Glu17-Semaglutide (CAS CATO-C4X-2226209)
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