(R)-3-(difluoromethoxy)pyrrolidine hydrochloride CAS 1638744-53-2
| CAS No. | 1638744-53-2 |
| Molecular Formula | C5H9F2NO |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(R)-3-(difluoromethoxy)pyrrolidine hydrochloride (CAS 1638744-53-2), molecular formula C5H9F2NOHCl and molecular weight 173.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of (R)-3-(difluoromethoxy)pyrrolidine hydrochloride (C5H9F2NOHCl) is characterized by an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H9F2NO HCl |
| Molecular Weight | 173.59 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 0.0 |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related R Standards
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- 3-(4-(Difluoromethoxy)phenyl)propanoic acid (CAS 1000932-18-2)
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- Methyl 6-(4-(difluoromethoxy)phenyl)-3-methylisoxazolo[5,4-b]pyridine-4-carboxylate (CAS 1011396-51-2)
Recommended Standards
- 3-[(2,2,2-Trifluoroethyl)sulfanyl]benzoyl chloride (CAS 1706430-16-1)
- (1R*,4R*)-tert-Butyl N-[4-(pyrimidin-4-ylamino)cyclohexyl]carbamate (CAS 1448855-00-2)
- tert-Butyl 3-amino-4-ethoxy-1-pyrrolidinecarboxylate (CAS 1497325-09-3)
- 2-(1,3-Dioxoisoindolin-2-yl)-3-(methylthio)propanoic acid (CAS 55582-20-2)
- 7-Benzyloxy-6-methoxy-1,4-dihydro-4-quinolinone (CAS 205448-29-9)
- 2-((5-((4-Fluorobenzyl)thio)-1,3,4-thiadiazol-2-yl)thio)-1-(4-methoxyphenyl)ethanone (CAS 477329-63-8)
- 3-Ethyl-1-oxa-4-azaspiro[5.5]Undecane (CAS 1481082-03-4)
- (2-Ethyl-piperidin-1-yl)-acetic acid 1411AF 878431-25-5 C9H17NO2 (CAS 878431-25-5)
- Methyl 7-bromo-5-methyl-4-oxo-4,5-dihydrothieno[3,2-c]pyridine-2-carboxylate (CAS 2461773-51-1)
- Semaglutide（sodium salt） (CAS CATO-C4X-222619)
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