2,2-Difluoro-2-(6-fluoro-1H-indol-3-yl)ethan-1-amine CAS 1638759-57-5
| CAS No. | 1638759-57-5 |
| Molecular Formula | C10H9F3N2 |
| Molecular Weight | 214.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2,2-Difluoro-2-(6-fluoro-1H-indol-3-yl)ethan-1-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2,2-Difluoro-2-(6-fluoro-1H-indol-3-yl)ethan-1-amine (CAS 1638759-57-5) is a high-purity analytical reference standard with the molecular formula C10H9F3N2 and a molecular weight of 214.19 g/mol.
The molecular framework of 2,2-Difluoro-2-(6-fluoro-1H-indol-3-yl)ethan-1-amine (C10H9F3N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H9F3N2 |
| Molecular Weight | 214.19 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
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- Ethyl 7-fluoroquinoline-8-carboxylate (CAS 1822843-84-4)
- 1,8-Diisocyanatooctane (CAS 10124-86-4)
- 4-Amino-2-(5-methyl-1,3,4-oxadiazol-2-yl)phenol (CAS 1091990-90-7)
- 3-Methylisoindolin-1-one (CAS 6091-76-5)
- 4,7-Dichlorobenzofuran-3-carboxylic acid (CAS 1489438-50-7)
- 4-(Triphenylsilyl)butan-1-ol (CAS 18751-36-5)
- Peptide YY (human) trifluoroacetate salt (CAS 118997-30-1)
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