tert-Butyl 6,6-difluoro-2-azaspiro[3.4]octane-2-carboxylate CAS 1638759-78-0
| CAS No. | 1638759-78-0 |
| Molecular Formula | C12H19F2NO2 |
| Molecular Weight | 247.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO manufactures tert-Butyl 6,6-difluoro-2-azaspiro[3.4]octane-2-carboxylate under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
tert-Butyl 6,6-difluoro-2-azaspiro[3.4]octane-2-carboxylate (CAS 1638759-78-0), molecular formula C12H19F2NO2 and molecular weight 247.28 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of tert-Butyl 6,6-difluoro-2-azaspiro[3.4]octane-2-carboxylate (C12H19F2NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C12H19F2NO2 |
| Molecular Weight | 247.28 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Recommended Standards
- 6-(Thiophen-2-ylmethoxy)-1H-purin-2-amine (CAS 162320-37-8)
- Tert-butyl 8,8-difluoro-2-azabicyclo[5.1.0]Octane-2-carboxylate (CAS 1704724-77-5)
- (2-(4-((Trifluoromethyl)thio)phenyl)cyclopropyl)methanamine (CAS 1468612-03-4)
- 2,6-Difluoro-4-(4-vinylcyclohexyl)benzonitrile (CAS 337366-98-0)
- Ubrogepant (CAS 1374248-77-7)
- 5-((3-Methyl-4-nitrophenoxy)methyl)furan-2-carbohydrazide (CAS 832737-79-8)
- 3-(3,4-Dimethoxyphenyl)-3-[4-(acetamidomethyl)benzenesulfonamido]propanoic acid (CAS 744230-56-6)
- 2-Benzylisothiazolidine 1,1-dioxide (CAS 91818-96-1)
- 5-Amino-1-(pyridin-2-ylmethyl)pyridin-2(1h)-one (CAS 1018457-71-0)
- 2'-Fluoro-2'-deoxy-ara-U-3'-phosphoramidite (CAS 1190089-70-3)
- (R)-1-(1H-Benzo[d]imidazol-1-yl)propan-2-amine (CAS 534620-19-4)
- 2-(1-Hydroxyethyl) promazine Sulfoxide (CAS 73644-42-5)
- 4-(Diphenylmethylene)-2-phenyloxazol-5(4H)-one (CAS 139517-52-5)
- Semaglutide Impurity 185 (CAS CATO-C4X-2226185)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
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