5-(Trifluoromethyl)piperidine-3-carboxylic acid CAS 1638772-08-3
| CAS No. | 1638772-08-3 |
| Molecular Formula | C7H10F3NO2 |
| Molecular Weight | 197.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
5-(Trifluoromethyl)piperidine-3-carboxylic acid (CAS 1638772-08-3) is a high-purity analytical reference standard with the molecular formula C7H10F3NO2 and a molecular weight of 197.16 g/mol.
The molecular framework of 5-(Trifluoromethyl)piperidine-3-carboxylic acid (C7H10F3NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H10F3NO2 |
| Molecular Weight | 197.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Trifluoromethyl Standards
- 6-(Trifluoromethyl)piperidine-3-carboxylic acid (CAS 1155103-14-2)
- Methyl 4-(trifluoromethyl)pyrrolidine-3-carboxylate (CAS 1190043-09-4)
- 7-(Trifluoromethyl)isoquinoline (CAS 1194375-56-8)
- 6-(Trifluoromethyl)isoquinoline (CAS 1194375-62-6)
- 4-(Trifluoromethyl)isoquinoline (CAS 120568-08-3)
- 8-(trifluoromethyl)isoquinoline (CAS 120568-10-7)
- 2-(Trifluoromethyl)piperidine-3-carboxylic acid (CAS 1240528-93-1)
- 2-(5-(Trifluoromethyl)pyrrolidin-2-yl)acetic acid (CAS 1258640-31-1)
Recommended Standards
- 4-(Trifluoromethyl)piperidine-2-carboxylic acid (CAS 1628734-92-8)
- 1-(5-Fluoro-2-methyl-3-nitrophenyl)ethanone (CAS 176548-78-0)
- Methyl 1-(2,2,2-trifluoroethyl)azetidine-2-carboxylate (CAS 1565672-01-6)
- Methyl 3-(trifluoromethyl)pyrrolidine-2-carboxylate (CAS 1779446-78-4)
- (3-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-1H-pyrazol-1-yl)(4-iodophenyl)methanone (CAS 477709-69-6)
- 3-(Dimethylamino)pyrrolidin-2-one (CAS 95797-36-7)
- (S)-5,6,7,8-Tetrahydroindolizin-7-amine (CAS 128916-00-7)
- Iclaprim (CAS 192314-93-5)
- Methyl (4S)-2-Oxo-3-piperidin-4-yl-1,3-oxazolidine-4-carboxylate hydrochloride (CAS 1217447-70-5)
- 1-((1R,5S)-3-amino-8-azabicyclo[3.2.1]Octan-8-yl)ethan-1-one (CAS 793662-76-7)
- Tert-butyl (1-(azetidin-3-yl)-2-hydroxyethyl)carbamate (CAS 2168772-02-7)
- 6-Hydrazinylnaphthalene-1,3-disulfonic acid (CAS 132557-71-2)
- 7-Bromo-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid hydrochloride (CAS 1260640-87-6)
- Des-Leu26-Tirzepatide (CAS CATO-CPTD788947)
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