Vortioxetine Impurity 27 CAS 1639263-80-1
| CAS No. | 1639263-80-1 |
| Molecular Formula | C18H22N2O2S |
| Molecular Weight | 330.44 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Vortioxetine Impurity 27 (CAS 1639263-80-1), a pharmacopoeial impurity reference standard (molecular formula C18H22N2O2S, MW 330.44 g/mol) used for the identification and quantification of trace impurities in APIs.
Vortioxetine Impurity 27 (C18H22N2O2S) contains a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H22N2O2S |
| Molecular Weight | 330.44 g/mol |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
Related Vortioxetine Standards
- Vortioxetine Impurity 32 (CAS CATO-C4X-105632)
- Vortioxetine Impurity 98 (CAS 1240670-87-4)
- Vortioxetine impurity 158 (CAS CATO-C4X-1056158)
- Vortioxetine Impurity 133 (CAS CATO-C4X-1056133)
- Vortioxetine Impurity 134 (CAS CATO-C4X-1056134)
- Vortioxetine Impurity 45 (CAS 2925447-38-5)
- Vortioxetine Impurity 31 (CAS 2135576-73-5)
- Vortioxetine Impurity 52 (CAS 1928741-88-1)
Recommended Standards
- Oxomemazine (CAS 3689-50-7)
- N-[(E)-(4-tert-Butylphenyl)methylideneamino]-4-methylbenzenesulfonamide (CAS 65609-73-6)
- Pioglitazone impurity 45 (CAS CATO-C4X-138345)
- N-(Benzo[d]thiazol-2-yl)-N-((tetrahydrofuran-2-yl)methyl)cyclopentanecarboxamide (CAS 852037-81-1)
- Umeclidinium Impurity 12 (CAS CATO-C4X-133912)
- Butylphthalide Impurity 44 (CAS CATO-C4X-181344)
- Gadoteridol Impurity 8 (CAS CATO-C4X-22578)
- 2-(Piperidin-4-yl)acetaldehyde (CAS 15848-30-3)
- 2-((1-Cyclohexylethyl)amino)-N,N-dimethylacetamide (CAS 1157911-14-2)
- Cefquinome (CAS 118443-88-2)
- Dalilesen impurity 24 (CAS CATO-C4X-301024)
- Ethyl 4-((methylamino)methyl)benzoate hydrochloride (CAS 1007870-76-9)
- (R)-(+)-1-Ethyl-2-pyrrolidinecarboxamide (CAS 381670-32-2)
- Neuroendocrine Regulatory Peptide-4 (human, mouse, rat) (H-7266.1000) (CAS 922704-18-5)
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