Atomoxetine EP Impurity D HCl CAS 1643684-05-2
| CAS No. | 1643684-05-2 |
| Molecular Formula | C17H21NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
CATO supplies Atomoxetine EP Impurity D HCl (CAS 1643684-05-2), a pharmacopoeial impurity reference standard (molecular formula C17H21NOHCl, MW 291.82 g/mol) used for the identification and quantification of trace impurities in APIs.
Atomoxetine EP Impurity D HCl (C17H21NOHCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H21NO HCl |
| Molecular Weight | 291.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Atomoxetine Standards
- Atomoxetine Impurity 50 (CAS 1007832-68-9)
- Atomoxetine impurity 40 (CAS 1010818-92-4)
- Atomoxetine impurity 41 (CAS 1010818-92-4（free base）)
- Atomoxetine EP Impurity C (CAS 1010818-96-8)
- Atomoxetine Impurity 9 HCl (CAS 1011-59-2)
- Atomoxetine EP impurity B (CAS 105314-53-2)
- Atomoxetine impurity 01 (CAS 109306-10-7)
- Atomoxetine EP Impurity H (S-Isomer) (CAS 114133-37-8)
Recommended Standards
- Diclofenac Impurity 24 (CAS CATO-C4X-105124)
- Lopinavir EP Impurity G (CAS CATO-C4X-16827)
- Tedizolid impurity 107 (CAS 1239662-42-0)
- N-((2,4-difluorophenyl)carbamothioyl)thiophene-2-carboxamide (CAS 900769-45-1)
- (4-Formylpiperazinyl)-N-((4-methylphenyl)sulfonyl)formamide (CAS 1023870-84-9)
- (2-Chloroethanesulfinyl)benzene (CAS 27998-60-3)
- Molybdenum(III) chloride (CAS 13478-18-7)
- N'-Hydroxy-3,5-dimethoxybenzenecarboximidamide (CAS 453566-08-0)
- 2-(1-Methyl-3-piperidinyl)benzoic acid (CAS 1524976-83-7)
- Semaglutide impurity 47 (CAS CATO-C4X-222647)
Why CATO?
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