4-chloro-1-(chloromethyl)-2-methylbenzene CAS 16470-09-0
| CAS No. | 16470-09-0 |
| Molecular Formula | C8H8Cl2 |
| Molecular Weight | 175.06 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 4-chloro-1-(chloromethyl)-2-methylbenzene.
CATO supplies 4-chloro-1-(chloromethyl)-2-methylbenzene (CAS 16470-09-0), a certified reference material (molecular formula C8H8Cl2, MW 175.06 g/mol) for analytical method development and quality control.
The molecular framework of 4-chloro-1-(chloromethyl)-2-methylbenzene (C8H8Cl2) is characterized by chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H8Cl2 |
| Molecular Weight | 175.06 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
Related chloro Standards
- 1-Chloro-2-(2-chloroethyl)benzene (CAS 1005-06-7)
- 2-Chloro-1-(chloromethyl)-3-methylbenzene (CAS 1261581-40-1)
- 1-Chloro-3-(chloromethyl)-5-methylbenzene (CAS 1261861-40-8)
- 1-Chloro-2-(1-chloroethyl)benzene (CAS 20001-64-3)
- 1-chloro-2-(chloromethyl)-3-methylbenzene (CAS 55676-90-9)
- 1-Chloro-2-(chloromethyl)-4-methylbenzene (CAS 34896-68-9)
- 1-chloro-3-(1-chloroethyl)benzene (CAS 34887-78-0)
- 1-Chloro-3-(2-chloroethyl)benzene (CAS 5182-43-4)
Recommended Standards
- (2,2-Dichloroethyl)benzene (CAS 4412-39-9)
- [6-(methylsulfanyl)pyridin-3-yl]boronic acid (CAS 321438-86-2)
- 4-Bromotoluene-2,3,5,6-d4 (CAS 112484-85-2)
- 1-(Dichloromethyl)-2-methylbenzene (CAS 60973-59-3)
- 2,6-Dichloro-4-(trifluoromethyl)aniline (CAS 24279-39-8)
- (Z)-2,3-Di(thiophen-2-yl)acrylic acid (CAS 716-33-6)
- trans-Dicyanobis(tricyclohexylphosphine)nickel(II) (CAS 65877-73-8)
- thieno[3,2-c]pyridine-4-carboxylic acid (CAS 1140239-91-3)
- 6-methoxy-1H-indazole-5-carbonitrile (CAS 473417-50-4)
- 2-((2,4,6-Trimethylbenzyl)oxy)ethan-1-amine (CAS 1250178-04-1)
- Azietomidate (CAS 711019-99-7)
- 4-Amino-2,3-dihydro-1H-inden-1-one (CAS 51135-91-2)
- 3-Propoxy-1H-pyrazol-5-amine (CAS 1043436-01-6)
- Insulin Degludec Impurity 20 (CAS CATO-C4X-215720)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com