6-Fluoroquinazoline CAS 16499-44-8
| CAS No. | 16499-44-8 |
| Molecular Formula | C8H5FN2 |
| Molecular Weight | 148.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 6-Fluoroquinazoline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
6-Fluoroquinazoline (CAS 16499-44-8), molecular formula C8H5FN2 and molecular weight 148.14 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Fluoroquinazoline (C8H5FN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-Fluoroquinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5FN2 |
| Molecular Weight | 148.14 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Fluoroquinazoline Standards
- 5-Fluoroquinazoline (CAS 16499-43-7)
- 7-Fluoroquinazoline (CAS 16499-45-9)
- 8-Fluoroquinazoline (CAS 195248-86-3)
- 2-Fluoroquinazoline (CAS 56595-08-5)
- 4-Fluoroquinazoline (CAS 56595-09-6)
- 6-Fluoroquinazoline-2,4-diamine (CAS 119584-77-9)
- 7-Fluoroquinazoline-2,4-diamine (CAS 119584-78-0)
- 8-Fluoroquinazoline-2,4-diamine (CAS 119584-79-1)
Recommended Standards
- 6-Fluoroquinoxaline (CAS 1644-14-0)
- 1H-1,2,3-triazole-5-sulfonamide (CAS 1935955-30-8)
- 1,3-Oxathiolane-2-carboxylicacid,5-oxo- (CAS 138760-34-6)
- Dimethyl(tetrahydrofuran-2-yl)phosphine oxide (CAS 134761-80-1)
- (4-Iodophenyl)(6-methoxypyridin-2-yl)methanone (CAS 1187171-28-3)
- ((2S,6R)-6-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-4-tritylmorpholin-2-yl)methyl dimethylphosphoramidochloridate (CAS 956139-30-3)
- Allyl 2-Ethylhexanoate (CAS 58105-49-0)
- N-(5-Benzoyl-4-phenylthiazol-2-yl)benzofuran-2-carboxamide (CAS 922472-94-4)
- N-(3,4-Dichlorophenyl)guanidine mononitrate (CAS 65783-11-1)
- 2-(Methyldisulfanyl)ethan-1-amine hydrochloride (CAS 131027-12-8)
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- (1H-Indol-1-yl)(phenyl)methanone (CAS 1496-76-0)
- 2,2,3,3,6-Pentafluoro-2,3-dihydrobenzo[b]thiophene-7-carbaldehyde (CAS 2413287-66-6)
- Palmitoyl Tetrapeptide-7 (CAS 221227-05-0)
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