6-(Trifluoromethyl)quinazoline CAS 16499-48-2
| CAS No. | 16499-48-2 |
| Molecular Formula | C9H5F3N2 |
| Molecular Weight | 198.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-(Trifluoromethyl)quinazoline.
6-(Trifluoromethyl)quinazoline (CAS 16499-48-2), molecular formula C9H5F3N2 and molecular weight 198.14 g/mol, is a CATO reference standard with documented purity and traceability.
6-(Trifluoromethyl)quinazoline (C9H5F3N2) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 6-(Trifluoromethyl)quinazoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H5F3N2 |
| Molecular Weight | 198.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related Trifluoromethyl Standards
- 5-(trifluoromethyl)pyridazine-3-carboxylic acid (CAS 1211535-95-3)
- 3-(Trifluoromethyl)-1,8-naphthyridine (CAS 1261365-77-8)
- 2-[4-(trifluoromethyl)-1H-pyrazol-1-yl]acetic acid (CAS 1341347-35-0)
- 2-(Trifluoromethyl)quinoxaline (CAS 148853-42-3)
- 4-(Trifluoromethyl)tetrahydro-2H-pyran-4-carboxylic acid (CAS 1524761-14-5)
- 5-(Trifluoromethyl)quinazoline (CAS 16499-47-1)
- 7-(Trifluoromethyl)quinazoline (CAS 16499-49-3)
- 8-(Trifluoromethyl)quinazoline (CAS 16499-50-6)
Recommended Standards
- 2-Ethynyl-5-(trifluoromethyl)benzaldehyde (CAS 1638606-24-2)
- 1-[(4R)-2,2-Dimethyl-1,3-Dioxolan-4-Yl]-2,2,2-Trifluoroethanone (CAS 162932-23-2)
- 1-(2,2,2-Trifluoroethoxymethyl)-cyclopropanecarboxylic acid (CAS 1698705-02-0)
- Isopropyl 4,4,4-trifluoroacetoacetate (CAS 175230-50-9)
- 4-(6-Aminopyridin-3-yl)-N-ethyl-2-fluorobenzamide (CAS 1314987-52-4)
- Benzyl 5-hydrazinyl-2-azabicyclo[2.2.1]heptane-2-carboxylate (CAS 1609467-59-5)
- 4-(Pyrimidin-4-yl)but-3-en-2-one (CAS 1344844-05-8)
- 2’-(Benzyloxy)-4’-bromoacetophenone (CAS 161385-97-3)
- 4-Chloro-6-methyl-furo[2,3-d]pyrimidine (CAS 24889-21-2)
- 2-Cyclohexylpropane-1,3-diol (CAS 2612-32-0)
- Quinacridonequinone (CAS 1503-48-6)
- 2-{[(9h-fluoren-9-yl)methoxy]carbonyl}-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid (CAS 1199776-90-3)
- (4-(Benzylamino)phenyl)methanol (CAS 145153-06-6)
- D-Gln24-Tirzepatide (CAS CATO-CPTD788910)
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