7-(Trifluoromethyl)isochroman CAS 165115-37-7
| CAS No. | 165115-37-7 |
| Molecular Formula | C10H9F3O |
| Molecular Weight | 202.17 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
7-(Trifluoromethyl)isochroman (CAS 165115-37-7), molecular formula C10H9F3O and molecular weight 202.17 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 7-(Trifluoromethyl)isochroman (C10H9F3O) is characterized by a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C10H9F3O |
| Molecular Weight | 202.17 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
Related Trifluoromethyl Standards
- 1-(2-Methyl-3-(trifluoromethyl)phenyl)ethan-1-one (CAS 1017778-01-6)
- 2-[4-(trifluoromethyl)phenyl]propanal (CAS 103108-04-9)
- (S)-4-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-ol (CAS 1202577-82-9)
- 4-(Trifluoromethyl)-2,3-dihydro-1H-inden-1-ol (CAS 1202577-87-4)
- 1-(Trifluoromethyl)-1-indanol (CAS 121692-27-1)
- 1-[4-(trifluoromethyl)phenyl]cyclopropan-1-ol (CAS 1224883-68-4)
- 2-(Trifluoromethyl)-2,3-dihydro-1H-inden-2-ol (CAS 1250172-63-4)
- (E)-3-(2-(Trifluoromethyl)phenyl)prop-2-en-1-ol (CAS 125617-14-3)
Recommended Standards
- 2’-(Trifluoromethyl)propiophenone (CAS 16185-96-9)
- Cinacalcet Impurity 25 (CAS 166947-09-7)
- 1-(2,4-Dimethylphenyl)-2,2,2-trifluoroethan-1-one (CAS 16184-87-5)
- 2-Methyl-2-(4-(trifluoromethyl)phenyl)oxirane (CAS 178180-81-9)
- N-(6-Ethoxybenzo[d]thiazol-2-yl)-2-(phenylthio)acetamide (CAS 775316-97-7)
- 5-Fluoro-2-(3-fluoro-5-(trifluoromethyl)pyridin-2-yl)-4-methyl-6-(methylthio)pyrimidine (CAS 1823183-51-2)
- 4-imidazolone-5-propanoate (CAS 17340-16-8)
- Methyl 4-ethoxy-3,5-dimethylbenzoate (CAS 1429903-28-5)
- (4-Chloro-3-fluorophenyl)(p-tolyl)methanol (CAS 842140-55-0)
- 2-Bromo-6-methyl-4-nitrophenyl trifluoromethanesulfonate (CAS 1403666-47-6)
- 5-Bromo-7H-benzo[c]carbazole (CAS 131409-18-2)
- Mesosulfuron-Methyl (CAS 208465-21-8)
- Ethyl 2,6-dichloro-4-(difluoromethoxy)benzoate (CAS 1804937-14-1)
- Insulin Degludec Impurity 5 (CAS CATO-C4X-21575)
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