N-Ethyl-2,6-difluoropyrimidin-4-amine CAS 165258-60-6
| CAS No. | 165258-60-6 |
| Molecular Formula | C6H7F2N3 |
| Molecular Weight | 159.14 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-Ethyl-2,6-difluoropyrimidin-4-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-Ethyl-2,6-difluoropyrimidin-4-amine (CAS 165258-60-6) is a high-purity analytical reference standard with the molecular formula C6H7F2N3 and a molecular weight of 159.14 g/mol.
Owing to a nitrile group, fluorine substitution, an aromatic ring system, N-Ethyl-2,6-difluoropyrimidin-4-amine is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 159.14 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H7F2N3 |
| Molecular Weight | 159.14 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- N-ethyl-4,6-difluoropyrimidin-2-amine (CAS 165258-59-3)
- 4,6-Difluoro-N,N-dimethylpyrimidin-2-amine (CAS 165258-63-9)
- 1-Aminocyclobutane-1,3-dicarboxylic acid (CAS 164225-42-7)
- 2-Aminobenzo[d]oxazole-5-carbonitrile (CAS 1654728-13-8)
- 2-(1,1-Dimethylethoxy)ethanol (CAS 7580-85-0)
- 5,11-Dimethyl-2-((1-(piperidin-4-yl)-1H-pyrazol-4-yl)amino)-5H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6(11H)-one (CAS 1628614-50-5)
- 5-(Isopropylthio)-1,3,4-thiadiazole-2-thiol (CAS 62868-67-1)
- 4-Cyclopropoxy-5-isopropyl-2-(trifluoromethyl)pyridine (CAS 1243396-33-9)
- 5,8-Dimethoxy-2-methylquinazolin-6-amine (CAS 1823498-67-4)
- (E)-6-phenylimidazo[2,1-b]thiazole-5-carbaldehyde O-(2,4-dichlorobenzyl) oxime (CAS 338395-43-0)
- 2-Phenylquinoline-3,4-dicarboxylic acid (CAS 133505-06-3)
- Methyl 3,5-difluoro-4-methylbenzoate (CAS 1806321-10-7)
- 1-(1H-Benzo[d][1,2,3]triazol-1-yl)octan-1-one (CAS 58068-80-7)
- Gastric Inhibitory Polypeptide (3-42) (human) trifluoroacetate salt (CAS 1802086-25-4)
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