N4-Ethyl-6-fluoropyrimidine-2,4-diamine CAS 165258-68-4
| CAS No. | 165258-68-4 |
| Molecular Formula | C6H9FN4 |
| Molecular Weight | 156.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N4-Ethyl-6-fluoropyrimidine-2,4-diamine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N4-Ethyl-6-fluoropyrimidine-2,4-diamine (CAS 165258-68-4) is a high-purity analytical reference standard with the molecular formula C6H9FN4 and a molecular weight of 156.16 g/mol.
The molecular framework of N4-Ethyl-6-fluoropyrimidine-2,4-diamine (C6H9FN4) is characterized by a nitrile group, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C6H9FN4 |
| Molecular Weight | 156.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 4 |
Recommended Standards
- 5-Fluoro-N,N-dimethyl-1H-pyrrole-2-carboxamide (CAS 156395-14-1)
- N2-Ethyl-6-fluoropyrimidine-2,4-diamine (CAS 165258-69-5)
- (2-fluoro-4-methoxyphenyl)hydrazine (CAS 154080-00-9)
- 6-Fluoro-N4,N4-dimethylpyrimidine-2,4-diamine (CAS 165258-70-8)
- 4-Isopropylbenzene-1,3-diamine (CAS 14235-45-1)
- 1-Propionylpiperidin-4-one (CAS 91623-91-5)
- methyl 2-amino-2-(thiophen-3-yl)acetate hydrochloride (CAS 107357-02-8)
- 1-(1-Methyl-1H-1,2,4-triazol-5-yl)methanamine dihydrochloride (CAS 2097897-81-7)
- 2-(Piperidin-2-yl)-1-(thiophen-2-yl)propan-1-one (CAS 1506884-94-1)
- 2-Methyl-5-phenyl-1,2-dihydro-3H-pyrazol-3-one (CAS 80030-92-8)
- 2-((3-(2-(Difluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)methoxy)benzaldehyde (CAS 1707576-19-9)
- 4-Methyl-6-(1-methyl-1H-pyrrol-2-yl)pyrimidin-2-amine (CAS 913322-68-6)
- 3-(Ethylamino)propanoic acid (CAS 10478-41-8)
- Des-[Gly]31-Semaglutide(x TFA Salt) (CAS 873874-39-6(free base))
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