达沙替尼杂质23 CAS 1654008-88-4
| CAS No. | 1654008-88-4 |
| Molecular Formula | C26H30ClN7O5S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 624.54 g/mol gives 达沙替尼杂质23 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
达沙替尼杂质23 (CAS 1654008-88-4) is a certified pharmaceutical impurity reference standard with the molecular formula C26H30ClN7O5SHCl and a molecular weight of 624.54 g/mol.
Owing to a steroid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage, chlorine substitution, 达沙替尼杂质23 is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 624.54 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H30ClN7O5S HCl |
| Molecular Weight | 624.54 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1993 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 7 |
| Sulfur Atoms | 1 |
Recommended Standards
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- 4-Bromooxazolo[4,5-c]pyridine-2(3H)-thione (CAS 1935599-70-4)
- Methyl 2-(3-chlorophenyl)-2-methylpropanoate (CAS 101233-58-3)
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- 3-(Aminomethyl)-N-(pyridin-3-ylmethyl)-1,2,4-oxadiazole-5-carboxamide (CAS 1119449-51-2)
- Crustacean Cardioactive Peptide (CCAP) (CAS 309247-84-5)
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