2-chloro-4-(trifluoromethyl)pyridin-3-amine CAS 166770-70-3
| CAS No. | 166770-70-3 |
| Molecular Formula | C6H10ClF3N2 |
| Molecular Weight | 202.61 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-chloro-4-(trifluoromethyl)pyridin-3-amine (CAS 166770-70-3), a certified reference material (molecular formula C6H10ClF3N2, MW 202.61 g/mol) for analytical method development and quality control.
The molecular framework of 2-chloro-4-(trifluoromethyl)pyridin-3-amine (C6H10ClF3N2) is characterized by fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
As a certified reference material (CRM), 2-chloro-4-(trifluoromethyl)pyridin-3-amine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H10ClF3N2 |
| Molecular Weight | 202.61 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
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Recommended Standards
- (S)-2-(3-chloro-5-fluorophenyl)propanoic acid (CAS 1630646-37-5)
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- (R)-2-(3-chloro-5-fluorophenyl)propanoic acid (CAS 1630473-60-7)
- 2-[(3-chloro-4-fluorophenoxy)methyl]oxirane (CAS 170876-52-5)
- trans-2-Undecenoic acid (CAS 15790-94-0)
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- (Glu9)-Exenatide (2-39) trifluoroacetate salt (CAS 196109-34-9)
- Methyl 3-bromo-4-((4-methylbenzyl)oxy)benzoate (CAS 1382775-12-3)
- 5-Methyl-6,8-dioxo-5,6,7,8-tetrahydro-1,5-naphthyridine-2,7-dicarbonitrile (CAS 2407907-25-7)
- 2-Phenylnicotinic Acid (CAS 33421-39-5)
- (7-Bromoisoquinolin-3-yl)methanol (CAS 1318897-45-8)
- 3,5-Dibromo-6-methoxy-2-aminopyrazine (CAS 1427500-63-7)
- 2-(5-Methyl-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile (CAS 2047352-75-8)
- Peptide Impurity 28 (CAS 1350456-64-2)
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