3-(Chloromethyl)-5-(methoxymethyl)isoxazole CAS 167155-52-4
| CAS No. | 167155-52-4 |
| Molecular Formula | C6H8ClNO2 |
| Molecular Weight | 161.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-(Chloromethyl)-5-(methoxymethyl)isoxazole (CAS 167155-52-4), molecular formula C6H8ClNO2 and molecular weight 161.59 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(Chloromethyl)-5-(methoxymethyl)isoxazole (C6H8ClNO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 3-(Chloromethyl)-5-(methoxymethyl)isoxazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H8ClNO2 |
| Molecular Weight | 161.59 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2004 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloromethyl Standards
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- 1-(5-(Chloromethyl)isoxazol-3-yl)ethanol (CAS 606488-98-6)
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- 4-(Chloromethyl)-5-fluoropyridin-2-ol (CAS 1227584-62-4)
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Recommended Standards
- 5-Chloro-1-(methoxymethyl)-3-methyl-1H-1,2,4-triazole (CAS 1630763-77-7)
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- 1-(2-Chloroacetyl)pyrrolidin-2-one (CAS 43170-60-1)
- N'-((2-Chloropyridin-3-yl)methylene)-4-methylbenzenesulfonohydrazide (CAS 204378-06-3)
- Allyl (3R,5R,6R)-6-(2-(2-((2,6-dichlorophenyl)amino)phenyl)acetoxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylate (CAS 698358-10-0)
- 889889-08-1 Z234897517 {1-[(4-methylphenyl)methyl]piperidin-4-yl}methanamine (CAS 889889-08-1)
- 2-[1-(3-Fluorophenyl)-1H-pyrazole-4-carbonyl]phenol (CAS 956624-10-5)
- 1-(2,5-Difluorophenyl)-1H-imidazole (CAS 1389313-64-7)
- 6,7-Dihydro-5H-cyclopenta[b]pyridin-3-ol (CAS 1211578-28-7)
- 1-benzyl-3-(3,4-dimethylphenyl)-1H-pyrazole-4-carboxylic acid (CAS 956199-09-0)
- 1-(4-chlorophenyl)-5-ethyl-2-sulfanylidene-1,3-diazinane-4,6-dione (CAS 1308650-31-8)
- 2-(4-Bromo-5-(3,4,5-trimethoxyphenyl)-4H-1,2,4-triazol-3-yl)-1-phenylethanethione (CAS 140405-98-7)
- [3-31]-Semaglutide D (Sodium salt) (CAS CATO-C4X-2226119)
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