4-Chloro-8-methoxyquinoline CAS 16778-21-5
| CAS No. | 16778-21-5 |
| Molecular Formula | C10H18ClNO |
| Molecular Weight | 203.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4-Chloro-8-methoxyquinoline is closely related to an amide group, a hydroxyl group, an ether linkage, chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 4-Chloro-8-methoxyquinoline (CAS 16778-21-5), a certified reference material (molecular formula C10H18ClNO, MW 203.71 g/mol) for analytical method development and quality control.
4-Chloro-8-methoxyquinoline (C10H18ClNO) contains an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 4-Chloro-8-methoxyquinoline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H18ClNO |
| Molecular Weight | 203.71 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 2-Chloro-n-(2-methylcyclohexyl)propanamide (CAS 1005099-41-1)
- 4-Chloro-1-ethyl-1H-indazol-3-amine (CAS 1015846-49-7)
- 4-chloro-8-methylquinazolin-2-amine (CAS 1026679-06-0)
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Recommended Standards
- 1-chloro-3-methoxy-isoquinoline (CAS 16535-95-8)
- 3-chloro-5-methoxy-isoquinoline (CAS 1691715-12-4)
- 2-chloro-5-methoxy-quinoline (CAS 160893-07-2)
- 4-chloro-7-methylquinazolin-2-amine (CAS 1780280-11-6)
- 1,3-Bis(2-methoxy-5-(trifluoromethyl)phenyl)urea (CAS 6064-14-8)
- 3-(Benzyloxy)-2-methyl-6-nitropyridine (CAS 2044705-03-3)
- 4-(Chloromethyl)-1-cyclohexyl-2-(trifluoromethyl)benzene (CAS 957205-24-2)
- 2-(3,4-Dimethoxyphenyl)-N-(thiophen-2-ylmethyl)ethan-1-amine (CAS 502935-35-5)
- 4-Tetrahydro-1h-pyrrol-1-ylpent-3-en-2-one (CAS 3389-57-9)
- Cis-4,5-diphenyl-3-(phenylsulfonyl)-4,5-dihydroisoxazole (CAS 85355-67-5)
- Fulvestrant impurity 57 (CAS CATO-C4X-191757)
- 3,4-dihydro-2H-1-benzopyran-3-carbaldehyde (CAS 944903-95-1)
- 4-Oxo-4-(2-propyl-1H-benzo[d]imidazol-1-yl)butanoic acid (CAS 378763-47-4)
- Des-[Gly]31-Semaglutide (CAS CATO-C4X-2226156)
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