2-(P-tolyloxy)-5-(trifluoromethyl)aniline CAS 16824-50-3
| CAS No. | 16824-50-3 |
| Molecular Formula | C14H12F3NO |
| Molecular Weight | 267.25 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), 2-(P-tolyloxy)-5-(trifluoromethyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
2-(P-tolyloxy)-5-(trifluoromethyl)aniline (CAS 16824-50-3) is a high-purity analytical reference standard with the molecular formula C14H12F3NO and a molecular weight of 267.25 g/mol.
The molecular framework of 2-(P-tolyloxy)-5-(trifluoromethyl)aniline (C14H12F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C14H12F3NO |
| Molecular Weight | 267.25 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related P Standards
- 4-(M-tolyloxy)-2-(trifluoromethyl)aniline (CAS 946784-66-3)
- 1-(2-(M-tolyloxy)ethyl)-1,3-dihydro-2h-benzo[d]imidazol-2-imine (CAS 325740-00-9)
- 1-(2-(o-Tolyloxy)ethyl)-1H-benzo[d]imidazol-2-amine (CAS 342398-08-7)
- 1-(2-(P-tolyloxy)ethyl)-1,3-dihydro-2h-benzo[d]imidazol-2-imine (CAS 325822-85-3)
- 5-((2-(M-tolyloxy)ethyl)thio)-1,3,4-thiadiazol-2-amine (CAS 565426-83-7)
- 5-((2-(P-tolyloxy)ethyl)thio)-1,3,4-thiadiazol-2(3h)-imine (CAS 420825-84-9)
- 3-(m-tolyloxy)propane-1,2-diyl diacetate (CAS CATO-C3D-262285)
- 3-(2-(m-Tolyloxy)ethyl)benzo[d]oxazol-2(3H)-one (CAS 868213-20-1)
Recommended Standards
- 2-(2-Fluorophenyl)quinoline-4-carboxylic acid (CAS 1647-89-8)
- 4-(Benzyloxy)-2-(trifluoromethyl)aniline (CAS 179246-24-3)
- 6-Fluoro-2-phenylquinoline-4-carboxylic Acid (CAS 1647-88-7)
- 2-(2-(Trifluoromethyl)phenyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrimidine (CAS 1799420-85-1)
- N-(Propan-2-yl)-2-[2-(trifluoromethyl)-1H-1,3-benzodiazol-1-yl]acetamide (CAS 672950-88-8)
- N-(4-(4-bromophenyl)thiazol-2-yl)hexanamide (CAS 461407-90-9)
- Methyl 2-(6-bromonaphthalen-2-yl)acetate (CAS 57421-65-5)
- Quinidine Impurity 2 (CAS 118-10-5)
- Methyl 4-((1,3-dioxo-1,3-dihydro-2H-inden-2-ylidene)methyl)benzoate (CAS 455321-49-0)
- Metaraminol Impurity 17 (CAS 54779-56-5)
- Tert-butyl (R)-3-(methylamino)butanoate (CAS 2171287-31-1)
- Everolimus Impurity 28 (CAS 102229-10-7)
- 4-(Methylamino)cyclohexanol hydrochloride (CAS 1955505-84-6)
- D-Phe22-Tirzepatide (CAS CATO-CPTD788912)
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