2-Methoxy-5-trifluoromethoxyphenylboronic acid pinacol ester CAS 1688666-59-2
| CAS No. | 1688666-59-2 |
| Molecular Formula | C14H18BF3O4 |
| Molecular Weight | 318.10 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 2-Methoxy-5-trifluoromethoxyphenylboronic acid pinacol ester (CAS 1688666-59-2), a certified reference material (molecular formula C14H18BF3O4, MW 318.10 g/mol) for analytical method development and quality control.
2-Methoxy-5-trifluoromethoxyphenylboronic acid pinacol ester (C14H18BF3O4) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
As a certified reference material (CRM), 2-Methoxy-5-trifluoromethoxyphenylboronic acid pinacol ester meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H18BF3O4 |
| Molecular Weight | 318.10 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.5 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
Related Methoxy Standards
- 2-(4-Methoxy-3-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1005009-96-0)
- 2-(5-Methoxy-2-(trifluoromethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1034669-93-6)
- 2-[3-Methoxy-4-(trifluoromethoxy)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 1623766-74-4)
- 2-Methoxy-4-(trifluoromethoxy)phenylboronic acid pinacol ester (CAS 2121514-61-0)
- 1-Methoxy-4-(1-phenylvinyl)benzene (CAS 4333-75-9)
- methyl 1-methoxy-4-(trifluoromethylsulfonyloxy)cyclohex-3-ene-1-carboxylate (CAS 2479340-24-2)
- 1-Methoxy-4-((((trifluoromethyl)sulfonyl)methyl)sulfonyl)benzene (CAS 204908-34-9)
- 2-(((2-Methoxy-4-nitrophenyl)amino)methylene)-5,5-dimethylcyclohexane-1,3-dione (CAS 330215-30-0)
Recommended Standards
- 4,4,5,5-Tetramethyl-2-(4-phenoxy-2-(trifluoromethoxy)phenyl)-1,3,2-dioxaborolane (CAS 1196395-85-3)
- N-Methyl 4-bromo-3-trifluoromethylbenzenesulfonamide (CAS 1020253-01-3)
- 4'-Hydroxydiclofenac-13C6 (CAS 1189656-64-1)
- Benzaldehyde, 3-iodo-5-methoxy-4-(2-propenyloxy)- (CAS 106331-79-7)
- 4-BRomo-3h-isobenzofuran-1-ylideneamine (CAS 2065250-40-8)
- 3'-Methyl-[1,1'-biphenyl]-3-thiol (CAS 845822-87-9)
- n-(3-Bromobenzyl)pyridin-3-amine (CAS 1019505-34-0)
- (5-Chloro-2-(methoxycarbonyl)pyridin-4-yl)boronic acid (CAS 2225176-71-4)
- 1-(3-Hydroxypropyl)-3-phenylthiourea (CAS 29146-63-2)
- 3-(2,6-Dichlorophenyl)propanenitrile (CAS 61698-06-4)
- 4-(5-Bromothiophen-2-yl)butanal (CAS 1341682-62-9)
- 2-[2-(3-Ethylphenoxy)ethyl]piperidinehydrochloride (CAS 1219968-13-4)
- Benzyl 3-bromo-4-chloro-5-methylbenzoate (CAS 2364585-21-5)
- Gastric Inhibitory Polypeptide (3-42) (human) trifluoroacetate salt (CAS 1802086-25-4)
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