Epinephrine Impurity 21 CAS 16899-83-5
| CAS No. | 16899-83-5 |
| Molecular Formula | C10H13NO3 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Structurally, Epinephrine Impurity 21 (C10H13NO3HCl) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 4.0, corresponding to approximately 4 ring(s) or double-bond equivalent(s). With a molecular weight of 231.68 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
As a process- or degradation-related impurity, Epinephrine Impurity 21 (CAS 16899-83-5, C10H13NO3HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H13NO3 HCl |
| Molecular Weight | 231.68 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1961 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Epinephrine Standards
- Epinephrine Impurity 10 (CAS 101724-21-4)
- Epinephrine Impurity 99 (CAS 1188265-23-7)
- Epinephrine Impurity 63 HCl (CAS 1188265-23-7 (free base))
- rac-Epinephrine-d3 (CAS 1189977-29-4)
- L-(-)-Epinephrine-d3 (CAS 1217733-17-9)
- (±)-Epinephrine-2,5,6,α,β,β-d6 (CAS 1219803-77-6)
- Epinephrine Sulfonic Acid-d3 (CAS 1346604-55-4)
- D-(+)-Epinephrine (CAS 150-05-0)
Recommended Standards
- Canagliflozin Impurity 111 (CAS CATO-C4X-1123111)
- Lusutrombopag Impurity 30 (CAS 1110767-19-5)
- Tegoprazan impurity 44 (CAS 1640981-11-8)
- 2,5-Dioxopyrrolidin-1-yl quinolin-5-ylcarbamate (CAS 148757-98-6)
- 3470-49-3 5-hydroxy-2,3-dihydroinden-1-one 5-oxidanyl-2,3-dihydroinden-1-one A822356 (CAS 3470-49-3)
- Methyl perfluorononanoate (CAS 51502-45-5)
- 2-Oxopiperidine-4-carbonitrile (CAS 1936013-85-2)
- 1-((1H-benzo[d]imidazol-2-yl)methyl)cyclohexan-1-amine (CAS 1435804-82-2)
- Brexpiprazole Impurity 78 DiHCl (CAS 2137823-20-0 (free base))
- Liraglutide-d8 Tetratrifluoroacetate (CAS 204656-20-2 (non-labelled, free base))
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