Fexofenadine Impurity N22 CAS 169032-11-5
| CAS No. | 169032-11-5 |
| Molecular Formula | C16H21ClO3 |
| Molecular Weight | 296.79 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 296.79 g/mol gives Fexofenadine Impurity N22 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
As a process- or degradation-related impurity, Fexofenadine Impurity N22 (CAS 169032-11-5, C16H21ClO3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Fexofenadine Impurity N22 (C16H21ClO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Fexofenadine Impurity N22 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C16H21ClO3 |
| Molecular Weight | 296.79 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2005 |
| Halogen Content | Cl-containing |
Related Fexofenadine Standards
- Fexofenadine Impurity 19 (CAS 193217-39-9)
- Fexofenadine Impurity 22 (CAS 343255-26-5)
- Fexofenadine Impurity 12 (CAS 154477-54-0)
- Fexofenadine Impurity 2 (CAS 169280-21-1)
- Fexofenadine Impurity 29 (CAS CATO-C4X-179429)
- Fexofenadine Impurity 13 (CAS 88783-30-6)
- Fexofenadine EP Impurity E (CAS 115-46-8)
- Fexofenadine Impurity 23 (CAS 169280-25-5)
Recommended Standards
- 4,4-[(4-Chlorophenyl)methylene]dimorpholine (CAS 16361-37-8)
- Methyl 4-chloro-3-(2-methoxyethoxy)-5-(methylthio)thiophene-2-carboxylate (CAS 1707609-79-7)
- 2-(Dimethylamino)-2-methylpropanal (CAS 16042-92-5)
- Tert-butyl 4-(3-chlorophenyl)piperazine-1-carboxylate (CAS 186790-11-4)
- Theophylline Impurity 12 (CAS CATO-C4X-182312)
- Valsartan Impurity 62 (CAS 1314799-75-1)
- Naltrexone Impurity 66 (CAS CATO-C4X-147566)
- (E)-2-(2-Nitrovinyl)Thiazole (CAS 1414580-91-8)
- 4-Chloro-6-(4-fluorophenyl)-2-(1-methoxyethyl)pyrimidine (CAS 1713713-39-3)
- 5-(2-Bromoacetyl)picolinonitrile (CAS 1445961-95-4)
- 3-Amino-1-(3-methylthiophen-2-yl)propan-1-ol (CAS 1499064-47-9)
- (2E)-N-(4-tert-Butylphenyl)-4-(4-ethoxyphenyl)-4-oxobut-2-enamide (CAS 331461-85-9)
- Methyl 4-(buta-1,3-dien-1-yl)benzoate (CAS 79201-20-0)
- Semaglutide impurity 75 (CAS CATO-C4X-222675)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com