4,6,7-trifluoro-1H-indole-2-carboxylic acid CAS 1699249-56-3
| CAS No. | 1699249-56-3 |
| Molecular Formula | C9H12F3NO2 |
| Molecular Weight | 223.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 4,6,7-trifluoro-1H-indole-2-carboxylic acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
4,6,7-trifluoro-1H-indole-2-carboxylic acid (CAS 1699249-56-3), molecular formula C9H12F3NO2 and molecular weight 223.19 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,6,7-trifluoro-1H-indole-2-carboxylic acid (C9H12F3NO2) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 4,6,7-trifluoro-1H-indole-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H12F3NO2 |
| Molecular Weight | 223.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related trifluoro Standards
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- 2',4,4'-Trifluoro-[1,1'-biphenyl]-3-amine (CAS 1219622-36-2)
- 3',4,4'-Trifluoro-[1,1'-biphenyl]-3-amine (CAS 1225761-19-2)
- 3',4,5'-Trifluoro-[1,1'-biphenyl]-3-amine (CAS 1226211-84-2)
- 3′,4′,5′-Trifluoro[1,1′-biphenyl]-4-amine (CAS 1248629-22-2)
- 4,5,6-trifluoro-1H-indole-2-carboxylic acid (CAS 884494-64-8)
- 2,2,2-Trifluoro-1-(5-fluoro-2-methoxyphenyl)ethan-1-amine (CAS 1039960-04-7)
Recommended Standards
- 6,7-Dinitro-1,2,3,4-tetrahydroisoquinoline (CAS 1644164-49-7)
- 4-Phenyl-3-(trifluoromethyl)pyridine (CAS 1803844-39-4)
- N-[1,2- (CAS 157668-96-7)
- 3-Phenyl-4-(trifluoromethyl)pyridine (CAS 1806299-81-9)
- Cyclopropyl(6-methylpyridin-2-yl)methanamine (CAS 1211162-77-4)
- Ethyl 6-cinnamyl-5,7-dimethylpyrazolo[1,5-a]pyrimidine-3-carboxylate (CAS 685108-00-3)
- (5Z)-3-{[(cyclopropylmethyl)(propyl)amino]methyl}-5-[(4-oxo-4H-chromen-3-yl)methylidene]-2-sulfanylideneimidazolidin-4-one (CAS 865659-89-8)
- (2E)-2-(1,3-Benzothiazol-2-yl)-3-(pyridin-4-yl)prop-2-enenitrile (CAS 1630975-99-3)
- 5-Bromo-N-(2-fluorobenzyl)nicotinamide (CAS 849684-40-8)
- 5-[(Chloroacetyl)amino]-2-hydroxybenzoic acid (CAS 80074-26-6)
- Ethyl 5-(tert-butyl)nicotinate (CAS 2117517-07-2)
- 4-Hydroxy-3-iodo-N-methylbenzamide (CAS 1243280-49-0)
- 8-Iodo-2,3-dihydro-[1,4]dioxino[2,3-b]pyridine (CAS 1228666-17-8)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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