5-Chloro-N-(2,4-dimethoxyphenyl)-2-iodopyrimidin-4-amine CAS 1704065-63-3
| CAS No. | 1704065-63-3 |
| Molecular Formula | C12H11ClIN3O2 |
| Molecular Weight | 391.59 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
5-Chloro-N-(2,4-dimethoxyphenyl)-2-iodopyrimidin-4-amine (C12H11ClIN3O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine/iodine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
CATO supplies 5-Chloro-N-(2,4-dimethoxyphenyl)-2-iodopyrimidin-4-amine (CAS 1704065-63-3), a certified reference material (molecular formula C12H11ClIN3O2, MW 391.59 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11ClIN3O2 |
| Molecular Weight | 391.59 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl/I-containing |
| Nitrogen Atoms | 3 |
Related Chloro Standards
- 2-((5-Chloro-7-iodoquinolin-8-yl)oxy)ethyl acetate (CAS 73511-39-4)
- 1-(6-Chloro-4-pyrimidinyl)-3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-methylurea (CAS 1802253-30-0)
- 5-Chloro-2-(2-(2,4-dichlorophenoxy)pyridin-3-yl)benzo[d]oxazole (CAS 866048-93-3)
- 5-Chloro-2-(2-(3,5-dichlorophenoxy)pyridin-3-yl)benzo[d]oxazole (CAS 866048-92-2)
- 5-Chloro-2-[2-(3,4-dichlorophenoxy)pyridin-3-yl]-1,3-benzoxazole (CAS 400085-49-6)
- 1-(4-Chloro-3-fluoro-2-iodo-phenyl)-4-(trifluoromethyl)triazole (CAS 2097065-63-7)
- 3-Chloro-N-((3-(2,6-difluorophenyl)-4,5-dihydroisoxazol-5-yl)methyl)-5-(trifluoromethyl)pyridin-2-amine (CAS 1209816-32-9)
- Ethyl 3-((3-chloro-5-(trifluoromethyl)pyridin-2-yl)(methyl)amino)-2,4-dioxo-3-azabicyclo[3.1.0]Hexane-6-carboxylate (CAS 318237-93-3)
Recommended Standards
- Ethyl 5-amino-1-(4-chlorophenyl)-4-iodo-1H-pyrazole-3-carboxylate (CAS 1427024-31-4)
- 1-(2,2-Diphenylethyl)-N-(3-(pyrrolidin-1-yl)propyl)piperidin-4-amine (CAS 827045-77-2)
- PALDA (CAS 136181-87-8)
- 1-Nitro-4-(octadecyloxy)benzene (CAS 123974-61-8)
- 2,4-Difluoro-6-methylphenylacetonitrile (CAS 1807192-55-7)
- (9H-Fluoren-9-yl)methyl (1H-pyrazol-3-yl)carbamate (CAS 1342457-33-3)
- (E)-3-nitro-4-(phenylthio)benzaldehyde O-(3,4-dichlorobenzyl) oxime (CAS 477852-25-8)
- 7-Octynylamine (7CI,8CI) (CAS 14502-43-3)
- Wilfornine A (CAS 345954-00-9)
- 2-Bromo-1-(2-hydroxy-3-methoxy-phenyl)-ethanone (CAS 1600533-09-2)
- 5-Chloro-2-fluorobenzonitrile (CAS 57381-34-7)
- 2-Iodo-4-(trifluoromethyl)benzoic Acid (CAS 54507-44-7)
- 4,5,6,7-Tetrahydro[1,2,4]triazolo[1,5-a]pyrimidine-2-carboxylic acid (CAS 1258649-77-2)
- Mast Cell Degranulating (MCD) Peptide (CAS 32908-73-9)
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