7-(Difluoromethyl)-2-(methylthio)-7,8-dihydroquinazolin-5(6H)-one CAS 1706433-08-0
| CAS No. | 1706433-08-0 |
| Molecular Formula | C10H10F2N2OS |
| Molecular Weight | 244.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 7-(Difluoromethyl)-2-(methylthio)-7,8-dihydroquinazolin-5(6H)-one (C10H10F2N2OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 7-(Difluoromethyl)-2-(methylthio)-7,8-dihydroquinazolin-5(6H)-one (CAS 1706433-08-0), a certified reference material (molecular formula C10H10F2N2OS, MW 244.26 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10F2N2OS |
| Molecular Weight | 244.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- Methyl (2S,5R)-5-(dibenzylamino)tetrahydro-2H-pyran-2-carboxylate (CAS 1398569-85-1)
- (2-Methoxy-4-(piperidin-1-yl)phenyl)boronic acid (CAS 2225179-31-5)
- 2-(3-Methylpiperidin-1-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isonicotinonitrile (CAS 1356087-25-6)
- 4-Chloro-8-methyl-5,6,7,8-tetrahydropteridin-6-one (CAS 1707394-13-5)
- 1,2,4,4A-tetrahydro-[1,4]oxazino[4,3-a]quinoline-5,5(6H)-dicarbonitrile (CAS 87699-07-8)
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