tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate CAS 1707358-38-0
| CAS No. | 1707358-38-0 |
| Molecular Formula | C18H25F3N2O2 |
| Molecular Weight | 358.40 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate (C18H25F3N2O2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate (CAS 1707358-38-0), molecular formula C18H25F3N2O2 and molecular weight 358.40 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C18H25F3N2O2 |
| Molecular Weight | 358.40 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 1-(3-(Trifluoromethyl)benzyl)piperidin-4-yl tert-butylcarbamate (CAS 1219623-99-0)
- Tert-butyl 4-amino-4-(2-(trifluoromethyl)benzyl)piperidine-1-carboxylate (CAS 1707602-37-6)
- (R,E)-2-amino-3-(1H-indol-3-yl)-N'-(quinoxalin-6-ylmethylene)propanehydrazide (CAS 1173671-63-0)
- Tert-butyl ((4-(4-(trifluoromethyl)phenyl)piperidin-4-yl)methyl)carbamate (CAS 1713163-32-6)
- 1,3-Benzenedicarboxylic acid, polymer with 2-ethyl-2-(hydroxymethyl)-1,3-propanediol, 3-hydroxy-2,2-dimethylpropyl 3-hydroxy-2,2-dimethylpropanoate and 2-oxepanone (CAS 41238-51-1)
- 2-((1-(2,5-Dichlorophenyl)ethyl)amino)propan-1-ol (CAS 1155572-71-6)
- Ethylmorphine-D5 (CAS 1309441-17-5)
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- 2-Bromo-5-methyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid (CAS 1782251-09-5)
- Ticagrelor Nitroso EP Impurity B (CAS CATO-C4X-1093164)
- (5-Bromopyridin-3-yl)(6,7-dihydrothieno[3,2-c]pyridin-5(4h)-yl)methanone (CAS 931066-44-3)
- 2-amino-2-cyclohexylacetic acid hydrochloride (CAS 212576-02-8)
- 5-(Phenylthio)benzene-1,3-diamine (CAS 245652-64-6)
- PACAP-Related Peptide (PRP), rat (CAS 132769-35-8)
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