5-Chloro-3-((2-fluorobenzyl)oxy)thiophene-2-carboxylic acid CAS 1707581-52-9

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-3-((2-fluorobenzyl)oxy)thiophene-2-carboxylic acid.

5-Chloro-3-((2-fluorobenzyl)oxy)thiophene-2-carboxylic acid (CAS 1707581-52-9), molecular formula C12H8ClFO3S and molecular weight 286.71 g/mol, is a CATO reference standard with documented purity and traceability.

5-Chloro-3-((2-fluorobenzyl)oxy)thiophene-2-carboxylic acid (C12H8ClFO3S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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