5-(2-Chloropyridin-3-yl)-3-(2-(difluoromethoxy)phenyl)-1,2,4-oxadiazole CAS 1708250-85-4
| CAS No. | 1708250-85-4 |
| Molecular Formula | C14H8ClF2N3O2 |
| Molecular Weight | 323.68 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 323.68 g/mol gives 5-(2-Chloropyridin-3-yl)-3-(2-(difluoromethoxy)phenyl)-1,2,4-oxadiazole distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-(2-Chloropyridin-3-yl)-3-(2-(difluoromethoxy)phenyl)-1,2,4-oxadiazole (CAS 1708250-85-4), molecular formula C14H8ClF2N3O2 and molecular weight 323.68 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C14H8ClF2N3O2, 5-(2-Chloropyridin-3-yl)-3-(2-(difluoromethoxy)phenyl)-1,2,4-oxadiazole contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 323.68 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8ClF2N3O2 |
| Molecular Weight | 323.68 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Related Chloropyridin Standards
- 5-(2-Chloropyridin-3-yl)-3-(4-(difluoromethoxy)phenyl)-1,2,4-oxadiazole (CAS 1708168-59-5)
- (4-((3-Chloropyridin-2-yl)oxy)piperidin-1-yl)(thiophen-3-yl)methanone (CAS 1448061-01-5)
- (4-Chloropyridin-2-yl)(4-(thiophen-3-ylmethyl)piperazin-1-yl)methanone (CAS 1183939-70-9)
- N-((2-chloropyridin-3-yl)carbamothioyl)-2-methoxybenzamide (CAS 866014-53-1)
- 5-(2-Chloropyridin-4-yl)-3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazole (CAS 1201442-25-2)
- 5-(2-Chloropyridin-4-yl)-3-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazole (CAS 1707576-18-8)
- 5-(2-Chloropyridin-3-yl)-3-(2-(trifluoromethyl)phenyl)-1,2,4-oxadiazole (CAS 1707609-19-5)
- 5-(2-Chloropyridin-3-yl)-3-(3-(trifluoromethyl)phenyl)-1,2,4-oxadiazole (CAS 1779125-19-7)
Recommended Standards
- 3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)thiophene-2-carboxylic acid (CAS 1823182-65-5)
- n-(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-n-ethylethanamine (CAS 2096341-29-4)
- 4-(4-chloro-2-nitrophenoxy)-3-methoxybenzoic acid (CAS 731003-79-5)
- N-(4-Chloro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzyl)-2-methylpropan-2-amine (CAS 2096333-91-2)
- 1-(2-(Trifluoromethyl)benzyl)cyclopropan-1-amine hydrochloride (CAS 29977-79-5)
- 3-Chloro-4-methyl-N-(2-(2-methyl-1H-indol-3-yl)ethyl)benzenesulfonamide (CAS 606133-71-5)
- 2-Chloro-3-(chloromethyl)-6-fluoroquinoline (CAS 948291-04-1)
- N-(6-(piperazin-1-yl)pyridazin-3-yl)methanesulfonamide (CAS 902836-96-8)
- 3-Bromo-2-(4,4-difluoropiperidin-1-yl)benzaldehyde (CAS 1707580-95-7)
- Perospirone Impurity 25 (CAS CATO-C4X-245825)
- 5-Methyl-5-(3,4,5-trimethoxyphenyl)imidazolidine-2,4-dione (CAS 200711-60-0)
- 2-Methylbenzofuran-5-carbaldehyde (CAS 204584-97-4)
- 2-Butyl-2,3-dihydro-1,2-benzoselenazol-3-one (CAS 60940-32-1)
- Insulin Degludec Impurity 27 (CAS CATO-C4X-215727)
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