(1R,2R)-Cyclobutane-1,2-dicarboxylic acid CAS 17224-72-5

Purity 97%+In StockPharmaceutical Standards
CAS No.17224-72-5
Molecular FormulaC6H8O4
Molecular Weight144.13 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

(1R,2R)-Cyclobutane-1,2-dicarboxylic acid CAS 17224-72-5 chemical structure

Description

(1R,2R)-Cyclobutane-1,2-dicarboxylic acid (CAS 17224-72-5), molecular formula C6H8O4 and molecular weight 144.13 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of (1R,2R)-Cyclobutane-1,2-dicarboxylic acid (C6H8O4) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC6H8O4
Molecular Weight144.13 g/mol
Purity97%+
StorageStore at 2-8°C, keep sealed and dry
Solubility (reference)Soluble in methanol, ethanol, DMSO, water
StabilityMay oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening
Degree of Unsaturation (DBE)3.0
UV AbsorptionUV-absorbing
CAS Registry Year (est.)1961

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