1,5-Bis(chloromethyl)naphthalene CAS 1733-76-2
| CAS No. | 1733-76-2 |
| Molecular Formula | C12H10Cl2 |
| Molecular Weight | 225.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1,5-Bis(chloromethyl)naphthalene is closely related to chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1,5-Bis(chloromethyl)naphthalene (CAS 1733-76-2), molecular formula C12H10Cl2 and molecular weight 225.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1,5-Bis(chloromethyl)naphthalene (C12H10Cl2) is characterized by chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1,5-Bis(chloromethyl)naphthalene under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C12H10Cl2 |
| Molecular Weight | 225.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl-containing |
Related Bis Standards
- 1,4-Bis(chloromethyl)naphthalene (CAS 6586-89-6)
- 1,8-Bis(chloromethyl)naphthalene (CAS 50585-29-0)
- 2,3-Bis(chloromethyl)naphthalene (CAS 2744-60-7)
- 2,6-Bis(chloromethyl)naphthalene (CAS 93036-77-2)
- 2-(chloromethyl)benzene-1-sulfonyl chloride (CAS 31910-66-4)
- 3-(Chloromethyl)benzene-1-sulfonyl Chloride (CAS 33065-46-2)
- 4-(Chloromethyl)-benzenesulfonyl Chloride (CAS 2389-73-3)
- 4,5-Bis(chloromethyl)thiophene-2-carboxylic acid (CAS 864174-03-8)
Recommended Standards
- Azelaic acid dichloride (CAS 123-98-8)
- (4,5-Dichloro-2-fluoro-3-methylphenyl)(methyl)sulfane (CAS 2586127-43-5)
- 1-(2,4-Dichloro-5-fluorophenyl)ethane-1-thiol (CAS 1183717-04-5)
- (R)-3-hydroxy-3-methyl-5-(phosphonooxy)pentanoic acid (CAS 73566-35-5)
- 1-(7-(2-Fluorophenyl)-4-hydroxythieno[3,2-d]pyrimidin-2-yl)piperidine-4-carboxylic acid (CAS 1242870-45-6)
- Crotoxin (CAS 9007-40-3)
- 2-Bromo-3-iodobenzoic acid (CAS 855198-37-7)
- tert-Butyl (4-(hydroxymethyl)thiazol-2-yl)carbamate (CAS 494769-44-7)
- Valsartan Impurity 144 (CAS 149690-12-0)
- Ethyl 4-(2-chlorophenyl)-2-methyl-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxylate (CAS 176383-21-4)
- 1,2,3,4-Tetrahydro-1-naphthylamine hydrochloride (CAS 49800-23-9)
- 3,3-Dimethyl-6-phenyl-3H-indole (CAS 398459-19-3)
- 1-(2-Aminoethyl)-1h-1,2,3-triazole-4-carboxylic acid (CAS 1232979-67-7)
- Heptapeptide-6 (CAS CATO-CPTD788823)
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