n-Isopropyl-4-(trifluoromethoxy)aniline CAS 174181-16-9
| CAS No. | 174181-16-9 |
| Molecular Formula | C10H12F3NO |
| Molecular Weight | 219.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 219.20 g/mol gives n-Isopropyl-4-(trifluoromethoxy)aniline distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
n-Isopropyl-4-(trifluoromethoxy)aniline (CAS 174181-16-9), molecular formula C10H12F3NO and molecular weight 219.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of n-Isopropyl-4-(trifluoromethoxy)aniline (C10H12F3NO) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12F3NO |
| Molecular Weight | 219.20 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related n Standards
- n-Isopropyl-3-(trifluoromethoxy)aniline (CAS 1020966-65-7)
- Methyl 1-isopropyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylate (CAS 1160246-42-3)
- 5-Isopropyl-3-methylpyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 1443279-67-1)
- 7-Isopropyl-2-methylpyrazolo[1,5-a]pyrimidine-5-carboxylic acid (CAS 1781684-21-6)
- 8-Isopropyl-2-methylimidazo[1,2-b]pyridazine-7-carboxylic acid (CAS 2434602-71-6)
- Isopropyl 1H-benzo[d]imidazol-2-ylcarbamate (CAS 36128-66-2)
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Recommended Standards
- N,N-Dimethyl-2-(3,4,5-trifluorophenoxy)ethanamine (CAS 1708924-46-2)
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- 3-(3-Methoxyphenyl)-4-nitro-1H-pyrazole (CAS 1707603-09-5)
- 3-(Benzylamino)-1,1,1-trifluoropropan-2-ol (CAS 178218-36-5)
- 2-Methyl-3-nitro-5-sulfamoylbenzoic acid (CAS 1315365-23-1)
- Methyl 5-((tert-butoxycarbonyl)amino)-3-methylpentanoate (CAS 2683070-99-5)
- Mobam (CAS 1079-33-0)
- 2-Cyclohexylbenzoic acid (CAS 97023-48-8)
- 3-[3,4-Bis(Ethoxymethoxy)phenyl]-1-[2,4,6-tris(ethoxymethoxy)phenyl]-2-propen-1-one (CAS 1076199-13-7)
- 4-Ethyl-5-(thiophen-2-yl)-4H-1,2,4-triazole-3-thiol (CAS 337473-17-3)
- 2-(6-Iodohex-2-ynoxy)oxane (CAS 532414-06-5)
- 1-[2-(tert-butoxycarbonylamino)ethyl]cyclopropanecarboxylic acid (CAS 1780876-37-0)
- 2-(4-(1-(tert-Butoxycarbonyl)piperidin-4-yl)-3-fluorophenoxy)acetic acid (CAS 2270906-29-9)
- 103244-41-3 Insulin-like Growth Factor-II fragment 33-40 Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg (CAS 103244-41-3)
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