3-Chloro-4-hydroxypiperidin-2-one CAS 174204-83-2
| CAS No. | 174204-83-2 |
| Molecular Formula | C5H8ClNO2 |
| Molecular Weight | 149.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-Chloro-4-hydroxypiperidin-2-one (CAS 174204-83-2), molecular formula C5H8ClNO2 and molecular weight 149.58 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C5H8ClNO2, 3-Chloro-4-hydroxypiperidin-2-one contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution; these features give the compound characteristic functional-group stretching vibrations in infrared spectroscopy. The molecular weight of 149.58 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C5H8ClNO2 |
| Molecular Weight | 149.58 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
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Recommended Standards
- 3-Methoxyazetidine-1-carbonyl chloride (CAS 1849382-35-9)
- (2S,4S)-4-Chloropyrrolidine-2-carboxylic acid (CAS 16214-30-5)
- (2S)-2-Amino-4-chloropent-4-enoic acid (CAS 55528-30-8)
- Vildagliptin Impurity 61 (CAS 16214-29-2)
- 6-Imino-1-methyl-1,6-dihydropyrimidin-4-amine (CAS 99419-02-0)
- 2-Phenylphthalazin-1(2H)-one (CAS 6266-49-5)
- (S)-1-Nicotinoylpyrrolidine-2-carboxylic acid (CAS 59834-37-6)
- Astragaloside III (CAS 84687-42-3)
- (2Z)-2-Cyano-N-[(1E)-{[(2,4-dichlorophenyl)methoxy]imino}methyl]-3-phenylprop-2-enamide (CAS 338976-66-2)
- N-(3-Cyanothiophen-2-yl)-3-methylisoxazole-5-carboxamide (CAS 946286-83-5)
- Varenicline Impurity 48 (CAS CATO-C4X-196248)
- Methyl 2,4-difluoro-5-formylbenzoate (CAS 1566530-21-9)
- Methyl 2-(3,3,3-trifluoropropylthio)acetate (CAS 1086277-19-1)
- Acetyl decapeptide-3 (CAS 935288-50-9)
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