2-Bromo-3,5-bis(trifluoromethyl)aniline CAS 174824-16-9
| CAS No. | 174824-16-9 |
| Molecular Formula | C8H4BrF6N |
| Molecular Weight | 308.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Bromo-3,5-bis(trifluoromethyl)aniline is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
2-Bromo-3,5-bis(trifluoromethyl)aniline (CAS 174824-16-9), molecular formula C8H4BrF6N and molecular weight 308.02 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Bromo-3,5-bis(trifluoromethyl)aniline (C8H4BrF6N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/bromine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Bromo-3,5-bis(trifluoromethyl)aniline meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H4BrF6N |
| Molecular Weight | 308.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2006 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Bromo Standards
- 4-Bromo-2,6-bis(trifluoromethyl)aniline (CAS 1805510-05-7)
- 2-Bromo-4,5-bis(trifluoromethyl)aniline (CAS 230295-15-5)
- 2-Bromo-4,6-bis(trifluoromethyl)aniline (CAS 243977-18-6)
- 4-Bromo-3,5-bis(trifluoromethyl)aniline (CAS 268733-18-2)
- 1-Bromo-3-(4-bromobutoxy)benzene (CAS 1044501-90-7)
- 1-Bromo-2-(4-bromobutoxy)benzene (CAS 105212-11-1)
- 1-Bromo-4-(2-bromo-1-ethoxyethyl)benzene (CAS 1248388-88-6)
- 1-Bromo-2-(2-bromo-1-ethoxyethyl)benzene (CAS 1249002-43-4)
Recommended Standards
- 2-Bromomethyl-4,6-bistrifluoromethyl-pyridine (CAS 1208080-58-3)
- 3-(Difluoromethyl)-5-formyl-6-iodopicolinonitrile (CAS 1804733-26-3)
- 4-Bromomethyl-3,5-bis-trifluoromethyl-pyridine (CAS 1204235-09-5)
- 4-Cyano-3-(difluoromethyl)-6-iodopyridine-2-carboxaldehyde (CAS 1805289-03-5)
- 1-Ethyl-N-(4-methylcyclohexyl)-1H-pyrazol-4-amine (CAS 1155578-14-5)
- 3-((1H-Indol-1-yl)sulfonyl)-4-chloroaniline (CAS 173908-48-0)
- (2-(4-Fluorophenyl)-5-methyloxazol-4-yl)methanol (CAS 109544-18-5)
- 5'-[(L-3-Amino-3-carboxypropyl)methylsulfonio]-5'-deoxyadenosine Disulfate 5'-[[(3S)-3-Amino-3-carboxypropyl]methylsulfonio]-5'-deoxyadenosine Disulfate 86867-01-8 Active Methionine Disulfate Active methionine Ademetionine Disulfate AdoMet L-S-Adenosylmethionin Disulfate S-(5 inverted exclamation marka-Adenosyl)-L-methionine chloride dihydrochloride S-(5'-Adenosyl)-L-methionine Disulfate Salt (Synthetic)(Mixture of Diastereomers) S-Adenosyl-L-methionine Disulfate S-Adenosylmethionine Disulfate SAM chloride dihydrochloride (CAS 86867-01-8)
- 2-((6-Acetamidopyridin-3-yl)thio)-N-(4-(trifluoromethoxy)phenyl)benzamide (CAS 338962-78-0)
- (R)-2-(2-Bromobenzyl)-1-(tert-butoxycarbonyl)pyrrolidine-2-carboxylic acid (CAS 706806-71-5)
- methyl 3-bromocyclobutane-1-carboxylate (CAS 4935-00-6)
- Boc-N-PEG2-Ms (CAS 302331-20-0)
- 4-Methylumbelliferyl phosphate bis(cyclohexylammonium) salt (CAS 128218-53-1)
- D-Pro31-Tirzepatide (CAS CATO-CPTD788905)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com