2-(Tert-butyl)-7-chloro-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine CAS 175203-38-0
| CAS No. | 175203-38-0 |
| Molecular Formula | C11H11ClF3N3 |
| Molecular Weight | 277.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
2-(Tert-butyl)-7-chloro-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (CAS 175203-38-0) is a high-purity analytical reference standard with the molecular formula C11H11ClF3N3 and a molecular weight of 277.67 g/mol.
Structurally, 2-(Tert-butyl)-7-chloro-5-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine (C11H11ClF3N3) contains a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 277.67 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C11H11ClF3N3 |
| Molecular Weight | 277.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 3 |
Recommended Standards
- 5-(2-Chloro-4-(trifluoromethyl)phenoxy)pentanenitrile (CAS 1443328-43-5)
- (5-Chloro-2-(trifluoromethyl)phenyl)(pyrrolidin-1-yl)methanone (CAS 2413441-11-7)
- 5-(2-Chloro-5-(trifluoromethyl)phenoxy)pentanenitrile (CAS 1443303-01-2)
- 6-Chloro-1-ethyl-2-methyl-5-(trifluoromethyl)-1H-benzo[d]imidazol-7-amine (CAS 53900-93-9)
- [1-(4-Chlorobenzyl)-2,5-dioxoimidazolidin-4-yl]acetic acid (CAS 1910769-52-6)
- N,N'-(4,4'-methylenebis(4,1-phenylene))bis(2,2,2-trichloroacetamide) (CAS 550299-55-3)
- Ethyl 5-bromo-2H-pyrazolo[3,4-b]pyridine-3-carboxylate (CAS 1131604-85-7)
- Phenanthro[1,10,9,8-opqra]perylene (CAS 190-39-6)
- 2-Methoxy-5-phenyl-3-(trifluoromethyl)pyridine (CAS 1214369-85-3)
- (2E)-3-[(4-Chloro-2-fluorophenyl)amino]-1-{4-[(2-chloro-6-fluorophenyl)methoxy]phenyl}prop-2-en-1-one (CAS 477888-62-3)
- 3-(((1-Ethyl-1H-pyrazol-5-yl)methyl)thio)propanoic acid (CAS 1172826-28-6)
- Trans-2-((2-methylfuran-3-yl)thio)cyclohexanol (CAS 61295-48-5)
- 1-(4-Amino-phenyl)-4-Cbz-piperazine (CAS 947673-12-3)
- Semaglutide impurity 97 (CAS CATO-C4X-222697)
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