4,5,7-Trichloro-2-(trifluoromethyl)quinoline CAS 175203-41-5
| CAS No. | 175203-41-5 |
| Molecular Formula | C10H3Cl3F3N |
| Molecular Weight | 300.49 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4,5,7-Trichloro-2-(trifluoromethyl)quinoline (CAS 175203-41-5), molecular formula C10H3Cl3F3N and molecular weight 300.49 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4,5,7-Trichloro-2-(trifluoromethyl)quinoline (C10H3Cl3F3N) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H3Cl3F3N |
| Molecular Weight | 300.49 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Trichloro Standards
- 2,3,4-Trichloro-6-(trifluoromethyl)quinoline (CAS 1447959-23-0)
- 4,6,8-Trichloro-2-(trifluoromethyl)quinoline (CAS 18706-37-1)
- 3,4,5-Trichloro-2-(trichloromethyl)pyridine (CAS 1201-30-5)
- 2,3,6-Trichloro-5-(trichloromethyl)pyridine (CAS 58584-80-8)
- 2,6,7-Trichloro-3-(trifluoromethyl)quinoxaline (CAS 281209-13-0)
- Trichloro(perfluorophenyl)silane (CAS 20083-38-9)
- 1262002-49-2 2',4',6-Trichloro[1,1'-biphenyl]-3-carboxylic acid DTXSID50691220 (CAS 1262002-49-2)
- 1,3,5-Trichloro-2-(trichloromethyl)benzene (CAS 14379-95-4)
Recommended Standards
- Allylestrenol (CAS 432-60-0)
- (1<I>R</I>,2<I>S</I>,5<I>R</I>)-(-)-menthol (<I>S</I>)-pair Toluene sulfinate (CAS 1517-82-4)
- 2-Hydroxyoctadecanoic acid (CAS 1330-70-7)
- 1-(6-Chloro-2-fluoro-3-iodophenyl)ethanol (CAS 2635937-66-3)
- 2-(2-Chloro-5-(trifluoromethyl)phenyl)propan-2-amine hydrochloride (CAS 1314666-26-6)
- 3-Formyl-6-methoxy-1-(2-methylbenzyl)-1H-indole-2-carboxylic acid (CAS 1242889-04-8)
- 3-Fluoro-5-methylbenzene-1,2-diol (CAS 127686-01-5)
- 4-(2-(5,7-Dimethyl-2-oxoindolin-3-ylidene)hydrazineyl)benzoic acid (CAS 756843-31-9)
- 1-Ethyl-1h-pyrazole-3-carboxamide (CAS 89464-90-4)
- Posaconazole Impurity 261 (CAS 2376724-98-8)
- Ethyl 5,8-difluoro-4-(piperazin-1-yl)quinoline-3-carboxylate (CAS 1315370-79-6)
- 3-Amino-5-hydroxy-1H-pyrazole-1-carboxamide (CAS 119769-05-0)
- Ethyl 4-oxo-2,4,5,6-tetrahydrocyclopenta[c]pyrazole-3-carboxylate (CAS 2089992-52-7)
- (D-His1)-Exenatide trifluoroacetate salt (CAS 1678417-09-8)
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