Irbesartan Impurity 2 CAS 177219-40-8
| CAS No. | 177219-40-8 |
| Molecular Formula | C11H20N2O2 |
| Molecular Weight | 212.29 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Irbesartan Impurity 2 (CAS 177219-40-8, C11H20N2O2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Irbesartan Impurity 2 (C11H20N2O2) contains an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H20N2O2 |
| Molecular Weight | 212.29 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 2007 |
| Nitrogen Atoms | 2 |
Related Irbesartan Standards
- Irbesartan Impurity 42 (CAS CATO-C4X-166642)
- Irbesartan Impurity 44 (CAS CATO-C4X-166644)
- Irbesartan Impurity 46 (CAS CATO-C4X-166646)
- Irbesartan Impurity 48 (CAS 253269-07-7)
- Irbesartan Impurity 23 (CAS CATO-C4X-166623)
- Irbesartan Impurity 3 (CAS 15026-80-9)
- Irbesartan impurity 37 (CAS 1415462-83-7)
- Irbesartan Impurity 17 (CAS CATO-C4X-166617)
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- 5-Nitrofuran-3-carboxamide (CAS 118739-51-8)
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- 2-Amino-4-chloro-3-methylbenzoic Acid (CAS 98968-68-4)
- 2-(2-Morpholinophenyl)acetonitrile (CAS 87698-86-0)
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