4-Chloro-5-nitronicotinic acid CAS 1774357-50-4

Description

The occurrence of 4-Chloro-5-nitronicotinic acid is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.

4-Chloro-5-nitronicotinic acid (CAS 1774357-50-4), molecular formula C6H3ClN2O4 and molecular weight 202.55 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of 4-Chloro-5-nitronicotinic acid (C6H3ClN2O4) is characterized by an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 4-Chloro-5-nitronicotinic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

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