4-Chloro-3-((2-chlorobenzyl)oxy)thiophene-2-carboxylic acid CAS 1774902-81-6
| CAS No. | 1774902-81-6 |
| Molecular Formula | C12H8Cl2O3S |
| Molecular Weight | 303.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
4-Chloro-3-((2-chlorobenzyl)oxy)thiophene-2-carboxylic acid (CAS 1774902-81-6), molecular formula C12H8Cl2O3S and molecular weight 303.16 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, 4-Chloro-3-((2-chlorobenzyl)oxy)thiophene-2-carboxylic acid is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 303.16 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H8Cl2O3S |
| Molecular Weight | 303.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Sulfur Atoms | 1 |
Related Chloro Standards
- 4-Chloro-3-((3-chlorobenzyl)oxy)thiophene-2-carboxylic acid (CAS 1707609-75-3)
- 5-Chloro-3-((4-chlorobenzyl)oxy)thiophene-2-carboxylic acid (CAS 1710661-40-7)
- 4-Chloro-3-((4-chlorobenzyl)oxy)thiophene-2-carboxylic acid (CAS 1779123-53-3)
- (2-Chloro-1,3-thiazol-5-yl)methyl N-(3-chlorophenyl)carbamate (CAS 341967-64-4)
- 300727-89-3 4-chloro-N-(5-chloropyridin-2-yl)benzene-1-sulfonamide Z45671549 (CAS 300727-89-3)
- 2-(6-Chloro-2-(5-chloropyridin-2-yl)imidazo[1,2-a]pyridin-3-yl)acetonitrile (CAS 88571-17-9)
- 4-Chloro-3-(ethylsulfonyl)benzenesulfonyl chloride (CAS 1354961-84-4)
- 5-Chloro-2-(methanesulfonylmethyl)benzene-1-sulfonyl chloride (CAS 1432678-37-9)
Recommended Standards
- 3-(Benzyloxy)-4,5-dichlorothiophene-2-carboxylic acid (CAS 1707727-88-5)
- 2-(4,5-Dimethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetonitrile (CAS 1831078-72-8)
- 6-Methoxy-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)isoindolin-1-one (CAS 1840966-84-8)
- 2,2-Dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-boronic Acid Pinacol Ester (CAS 1650548-32-5)
- 2-Chloro-6-hydrazinylpyridine-4-carbonitrile (CAS 107445-56-7)
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