3-[1-(4-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one CAS 1775454-98-2
| CAS No. | 1775454-98-2 |
| Molecular Formula | C20H19ClN4O2 |
| Molecular Weight | 382.84 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 3-[1-(4-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one.
3-[1-(4-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775454-98-2), molecular formula C20H19ClN4O2 and molecular weight 382.84 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 3-[1-(4-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 382.84 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 3-[1-(4-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C20H19ClN4O2 |
| Molecular Weight | 382.84 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 4 |
Related Chlorobenzoyl Standards
- 3-[1-(3-Chlorobenzoyl)piperidin-4-yl]-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one (CAS 1775518-98-3)
- 5-[1-(3-Chlorobenzoyl)pyrrolidin-2-yl]-3-(4-methoxyphenyl)-1,2,4-oxadiazole (CAS 855129-92-9)
- N'-(3-chlorobenzoyl)thieno[2,3-b]quinoline-2-carbohydrazide (CAS 478079-50-4)
- N'-(3-chlorobenzoyl)-8-methyl-8H-thieno[2,3-b]indole-2-carbohydrazide (CAS 477869-02-6)
- (2E)-3-[4-(3-Chlorobenzoyl)-1-methyl-1H-pyrrol-2-yl]-2-[5-(dimethylamino)-1,3,4-oxadiazol-2-yl]prop-2-enenitrile (CAS 338978-23-7)
- 4-[5-(4-Chlorobenzoyl)-3-(pyridin-2-yl)thiophen-2-yl]morpholine (CAS 339023-17-5)
- 3-(4-Chlorobenzoyl)-4-(2-fluorophenyl)-1-phenylpyrrolidine (CAS 343374-90-3)
- N'-(4-chlorobenzoyl)-3-(1H-pyrrol-1-yl)benzofuran-2-carbohydrazide (CAS 866040-18-8)
Recommended Standards
- N-(1-(6-(2-Chlorophenyl)pyridazin-3-yl)piperidin-4-yl)furan-2-carboxamide (CAS 1396855-05-2)
- 5-Chloro-1-methyl-3-phenyl-4-(((3-(trifluoromethyl)phenyl)thio)methyl)-1H-pyrazole (CAS 318234-16-1)
- (5Z)-5-({4-[(2-chloro-1,3-thiazol-5-yl)methoxy]-3-methoxyphenyl}methylidene)-1,3-thiazolidine-2,4-dione (CAS 866131-59-1)
- 5-[(6-Chloropyridin-3-yl)methylidene]-3-phenyl-2-[(4H-1,2,4-triazol-4-yl)imino]-1,3-thiazolidin-4-one (CAS 478078-00-1)
- 2-(5-Methyl-3-trifluoromethyl-pyrazol-1-yl)-propionyl chloride (CAS 1171649-27-6)
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Why CATO?
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