(E)-4-Hydroxy Toremifene (~5% Z-isomer) CAS 177748-22-0
| CAS No. | 177748-22-0 |
| Molecular Formula | C26H28ClNO2 |
| Molecular Weight | 421.96 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
(E)-4-Hydroxy Toremifene (~5% Z-isomer) (CAS 177748-22-0), molecular formula C26H28ClNO2 and molecular weight 421.96 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, (E)-4-Hydroxy Toremifene (~5% Z-isomer) (C26H28ClNO2) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 13.0, corresponding to approximately 13 ring(s) or double-bond equivalent(s). With a molecular weight of 421.96 g/mol, it falls into the moderately-high-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C26H28ClNO2 |
| Molecular Weight | 421.96 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related E Standards
- 4-Hydroxy Toremifene (CAS 110503-62-3)
- 4-Hydroxy Toremifene(~8% E isomer) (CAS 352233-94-4)
- 4-Hydroxy Clomiphene (CAS 79838-51-0)
- 2'-Hydroxy-[1,1':4',1''-terphenyl]-3,3'',5,5''-tetracarboxylic acid (CAS 1961231-34-4)
- 2-Hydroxy Estradiol 6-N3-Adenine (CAS 912671-55-7)
- 3-Hydroxy-4-(4-methylbenzoyl)-1-(3-morpholinopropyl)-5-(pyridin-4-yl)-1H-pyrrol-2(5H)-one (CAS 381199-47-9)
- 4-Hydroxy Estradiol 1-N3-Adenine (CAS 428506-88-1)
- 6'-Hydroxy-2'-(hydroxymethyl)-1'-methyl-6-(4-methylpiperazin-1-yl)-1H,1'H-[2,5'-bibenzo[d]imidazole]-4',7'-dione (CAS 188299-92-5)
Recommended Standards
- 2-((3-(sec-Butyl)-4-oxo-3,4-dihydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(2-chlorobenzyl)acetamide (CAS 1326859-59-9)
- N-tert-Butoxycarbonyl Amoxapine-d8 (CAS 1246814-71-0)
- N-(3-Chloro-2-methylphenyl)-2-((3-ethyl-5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)thio)acetamide (CAS 335399-64-9)
- N-(3-chloro-4-methylphenyl)-2-(2-((phenylthio)methyl)-1H-benzo[d]imidazol-1-yl)acetamide (CAS 339100-68-4)
- 7,8-Dinitro-2,3-dihydrobenzo[b][1,4]dioxin-6-amine (CAS 855222-38-7)
- 4-Methyl-2-pentyl-1,3-dioxolane (CAS 1599-49-1)
- 6-Amino-5-((4-chlorophenyl)sulfonyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile (CAS 338774-48-4)
- 3-(3-Phenoxyphenyl)propanoic acid (CAS 52888-70-7)
- 5-(1-Ethylpyrrolidin-2-yl)-2-methoxy-4-methylpyridine (CAS 1352519-44-8)
- 3-(3-Chlorophenyl)-1-propylamine (CAS 18655-49-7)
- (3-(1-((2-Fluoro-[1,1'-biphenyl]-4-yl)oxy)ethyl)-1H-pyrazol-1-yl)(4-fluorophenyl)methanone (CAS 477709-66-3)
- [3-(Pyridin-4-yl)-1,2,4-oxadiazol-5-yl]methanamine dihydrochloride (CAS 1181458-05-8)
- N-(4-Chlorobutyl)quinoline-4-carboxamide (CAS 502708-41-0)
- Semaglutide Impurity 166 (CAS 1395881-03-4)
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