3-(Difluoromethoxy)-5-(2-methoxyethoxy)thiophene-2-carboxylic acid CAS 1779122-72-3
| CAS No. | 1779122-72-3 |
| Molecular Formula | C9H10F2O5S |
| Molecular Weight | 268.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
3-(Difluoromethoxy)-5-(2-methoxyethoxy)thiophene-2-carboxylic acid (C9H10F2O5S) contains a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
3-(Difluoromethoxy)-5-(2-methoxyethoxy)thiophene-2-carboxylic acid (CAS 1779122-72-3) is a high-purity analytical reference standard with the molecular formula C9H10F2O5S and a molecular weight of 268.23 g/mol.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 3-(Difluoromethoxy)-5-(2-methoxyethoxy)thiophene-2-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H10F2O5S |
| Molecular Weight | 268.23 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Sulfur Atoms | 1 |
Related Difluoromethoxy Standards
- methyl 5-[4-(difluoromethoxy)phenyl]-1h-pyrazole-3-carboxylate (CAS 1092774-03-2)
- 1-Benzyl-5-(difluoromethoxy)-1H-pyrazole-3-carboxylic acid (CAS 1710661-08-7)
- 2'-(Difluoromethoxy)-3'-(trifluoromethyl)propiophenone (CAS 1261605-47-3)
- 1-(4-(Difluoromethoxy)-2-(trifluoromethyl)phenyl)propan-1-one (CAS 1261616-55-0)
- 1-[4-(difluoromethoxy)phenyl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid (CAS 1020253-48-8)
- n-(2-(Difluoromethoxy)phenyl)thiophene-2-carboxamide (CAS 674362-88-0)
- 2-(Difluoromethoxy)-3-nitro-5-(pyridin-4-yl)pyridine (CAS 1214390-87-0)
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Recommended Standards
- Allopurinol Riboside (CAS 16220-07-8)
- 5,6-Dimethyl-2-(4-(trifluoromethyl)phenyl)pyrimidin-4-ol (CAS 180606-46-6)
- 4-Oxo-1-(6-(trifluoromethyl)pyridin-3-yl)cyclohexanecarbonitrile (CAS 1600498-51-8)
- 4-(benzyloxy)-2-(trifluoromethyl)phenol (CAS 1881289-35-5)
- N,N-Dimethylpiperidine-3-carboxamide (CAS 5505-20-4)
- 3-Amino-1-((1R,2R)-2-fluorocyclopropyl)pyridin-2(1H)-one (CAS 2271476-14-1)
- 2-amino-3-cycloheptyl-propanoic acid;hydrochloride (CAS 499158-67-7)
- 2-(Aminomethyl)-3-methoxy-5-(trifluoromethoxy)pyridin-4-amine (CAS 1803704-64-4)
- 2-Butenedioic acid (2Z)-, 1-methyl ester, polymer with ethenyl acetate and 2,5-furandione (CAS 63528-95-0)
- Methyl 6-cyano-2-formylnicotinate (CAS 1374649-95-2)
- 1-((2R,4S)-4-Ethyl-2-methylpyrrolidin-1-yl)ethanone (CAS 101347-71-1)
- 1-(Pyrrolidin-3-yl)-1H-1,3-benzodiazole dihydrochloride (CAS 1461706-03-5)
- 2,2,4,4-tetramethyl-6,6-diphenyl-1,3,5,2,4,6-trioxatrisilinane (CAS 1693-51-2)
- Liraglutide Impurity 31 (CAS CATO-C4X-199231)
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