6-(Trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine CAS 1780-78-5
| CAS No. | 1780-78-5 |
| Molecular Formula | C18H20BrClN6O16P4 |
| Molecular Weight | 815.63 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Owing to a flavonoid core, an amide group, a phosphate ester group, a hydroxyl group, an ether linkage, chlorine/bromine substitution, 6-(Trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine is typically pale yellow to yellow amorphous powder. Its solid-state physicochemical attributes — including a molecular weight of 815.63 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
6-(Trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (CAS 1780-78-5), molecular formula C18H20BrClN6O16P4 and molecular weight 815.63 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 6-(Trifluoromethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H20BrClN6O16P4 |
| Molecular Weight | 815.63 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | Cl/Br-containing |
| Nitrogen Atoms | 6 |
Related Trifluoromethyl Standards
- 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(1S,2S)-2-[(11bR)-3,5-dihydro-4H-dinaphth[2,1-c:1',2'-e]azepin-4-yl]-1,2-diphenylethyl]amino]-3-cyclobutene-1,2-dione (CAS 1353884-38-4)
- 3-[[3,5-Bis(trifluoromethyl)phenyl]amino]-4-[[(1S,2S)-2-[(11bR)-3,5-dihydro-4H-dinaphth[2,1-c:1',2'-e]azepin-4-yl]-1,2-diphenylethyl]amino]-3-cyclobutene-1,2-dione (CAS 1542197-69-2)
- 3-(3,5-Bis(trifluoromethyl)phenyl)-1-(2'-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)-[1,1'-binaphthalen]-2-yl)-1-isopropylurea (CAS 2227157-04-0)
- 3-(3,5-Bis(trifluoromethyl)phenyl)-1-(7'-(3-(3,5-bis(trifluoromethyl)phenyl)ureido)-[1,1'-binaphthalen]-2-yl)-1-isopropylurea (CAS 2227157-06-2)
- Bis((trifluoromethyl)sulfonyl)methane (CAS 428-76-2)
- 5',5''''-((2,5-Bis(trifluoromethyl)-1,4-phenylene)bis(ethyne-2,1-diyl))bis(([1,1':3',1''-terphenyl]-4,4''-dicarboxylic acid)) (CAS 2476800-65-2)
- S-(4-(trifluoromethyl)benzyl) O-((2R,3R,4S,5R,6R)-3,4,5-tris(benzyloxy)-6-((benzyloxy)methyl)tetrahydro-2H-pyran-2-yl) (Z)-(4-(trifluoromethyl)phenyl)carbonimidothioate (CAS 468095-63-8)
- 3-[[[3,5-Bis(trifluoromethyl)phenyl]methyl]amino]-4-[[(1S,2S)-2-[(11bR)-3,5-dihydro-4H-dinaphth[2,1-c:1',2'-e]azepin-4-yl]cyclohexyl]amino]-3-cyclobutene-1,2-dione (CAS 1323997-09-6)
Recommended Standards
- n-Octapentacontane (CAS 7667-78-9)
- 2,2,4,4,6,6,8,8,10,10,12,12,14,14,16,16,18,18,20,20,22,22-Docosamethyl-1,3,5,7,9,11,13,15,17,19,21-undecaoxa-2,4,6,8,10,12,14,16,18,20,22-undecasilacyclodocosane (CAS 18766-38-6)
- Amlodipine Impurity 147 (CAS CATO-C4X-1095147)
- Bizelesin (CAS 129655-21-6)
- Methyl 4-Chloro-5-azaindole-2-carboxylate (CAS 688357-19-9)
- 2-Bromo-3-(difluoromethyl)aniline (CAS 1261495-66-2)
- Methyl 2-methoxybenzimidate hydrochloride (CAS 1125846-36-7)
- 2-(Trifluoromethyl)-6,7,8,9-tetrahydro-4H-pyrimido[1,2-a]pyrimidin-4-one (CAS 1566706-02-2)
- 5-Amino-2-((5-methyl-1,3,4-thiadiazol-2-yl)amino)pyrimidin-4(1H)-one (CAS 77961-53-6)
- (E)-3-Benzylidenedihydrofuran-2(3H)-one (CAS 30959-91-2)
- 4-(4-bromo-3-cyclopropyl-1H-pyrazol-1-yl)butanoic acid (CAS 1006495-46-0)
- 2-(1H-Indazol-3-yl)ethanamineHCl (CAS 1258504-46-9)
- Alfuzosin-d3 Hydrochloride (CAS 1216383-97-9)
- Semaglutide Impurity 139 (CAS CATO-C4X-2226139)
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