2,4-Difluoro-5-nitrobenzene-1-sulfonyl chloride CAS 1780-83-2
| CAS No. | 1780-83-2 |
| Molecular Formula | C6H2ClF2NO4S |
| Molecular Weight | 257.60 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,4-Difluoro-5-nitrobenzene-1-sulfonyl chloride (CAS 1780-83-2) is a high-purity analytical reference standard with the molecular formula C6H2ClF2NO4S and a molecular weight of 257.60 g/mol.
The molecular framework of 2,4-Difluoro-5-nitrobenzene-1-sulfonyl chloride (C6H2ClF2NO4S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 2,4-Difluoro-5-nitrobenzene-1-sulfonyl chloride under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C6H2ClF2NO4S |
| Molecular Weight | 257.60 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO, water |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Difluoro Standards
- 2,3-Difluoro-5-nitrobenzene-1-sulfonyl chloride (CAS 1156136-97-8)
- 2,6-Difluoro-4-nitrobenzene-1-sulfonyl chloride (CAS 1193388-31-6)
- 4,5-Difluoro-2-nitrobenzene-1-sulfonyl chloride (CAS 1394083-84-1)
- 3,4-Difluoro-5-nitrobenzene-1-sulfonyl chloride (CAS 1803826-81-4)
- 3,5-Difluoro-4-nitrobenzenesulfonyl chloride (CAS 1803870-67-8)
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Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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