5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid CAS 1780631-95-9
| CAS No. | 1780631-95-9 |
| Molecular Formula | C8H12F3N3O2 |
| Molecular Weight | 239.19 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 239.19 g/mol gives 5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (CAS 1780631-95-9) is a high-purity analytical reference standard with the molecular formula C8H12F3N3O2 and a molecular weight of 239.19 g/mol.
5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (C8H12F3N3O2) contains an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H12F3N3O2 |
| Molecular Weight | 239.19 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related trifluoromethyl Standards
- 5-trifluoromethyl-1H-pyrazolo[3,4-b]pyridine-3-carboxylic acid (CAS 1256820-22-0)
- 5-(3-(Trifluoromethyl)phenyl)pyridin-3-ol (CAS 1261800-66-1)
- 3-Oxo-1-(3-(trifluoromethyl)phenyl)cyclobutanecarbonitrile (CAS 1379098-58-4)
- 4-(5-(Trifluoromethyl)pyridin-2-yl)phenol (CAS 139218-75-0)
- 1-(7-(Trifluoromethyl)quinolin-3-yl)ethanone (CAS 1396546-96-5)
- 3-Oxo-1-(4-(trifluoromethyl)phenyl)cyclobutanecarbonitrile (CAS 1432048-86-6)
- 6-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (CAS 1538113-30-2)
- 1-(4-(Trifluoromethyl)phenyl)-1H-pyrrole-2-carbaldehyde (CAS 156496-70-7)
Recommended Standards
- 7-(trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyridine-3-carboxylic acid (CAS 1629012-68-5)
- 4-(4-(Trifluoromethoxy)phenyl)pyridine (CAS 191602-61-6)
- (1R,2R)-1-benzoyl-2-(trifluoromethyl)cyclopropane-1-carbonitrile (CAS 557796-53-9)
- 1-(2-(Trifluoromethyl)phenyl)-1H-pyrrole-2-carbaldehyde (CAS 312303-90-5)
- Methyl 2-amino-2-(2-methoxyphenyl)acetate hydrochloride (CAS 390815-44-8)
- N-(2-Ethylphenyl)thiourea (CAS 22265-77-6)
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