Methyl 5-amino-2-chloropyrimidine-4-carboxylate CAS 1780950-16-4
| CAS No. | 1780950-16-4 |
| Molecular Formula | C6H6ClN3O2 |
| Molecular Weight | 187.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Methyl 5-amino-2-chloropyrimidine-4-carboxylate is closely related to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Methyl 5-amino-2-chloropyrimidine-4-carboxylate (CAS 1780950-16-4), molecular formula C6H6ClN3O2 and molecular weight 187.58 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, chlorine substitution, an aromatic ring system, Methyl 5-amino-2-chloropyrimidine-4-carboxylate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 187.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), Methyl 5-amino-2-chloropyrimidine-4-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H6ClN3O2 |
| Molecular Weight | 187.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Methyl Standards
- 4-Amino-2-chloro-6-methyl-3-nitropyridine (CAS 1026907-18-5)
- 3-Amino-5-chloro-4-hydroxybenzoic acid (CAS 1042055-74-2)
- Methyl 2-amino-4-chloropyrimidine-5-carboxylate (CAS 1353503-49-7)
- Methyl 5-amino-6-chloropyrazine-2-carboxylate (CAS 1378678-66-0)
- Methyl 3-Amino-6-chloropyrazine-2-carboxylate (CAS 1458-03-3)
- 2-Amino-5-chloro-4-methyl-3-nitropyridine (CAS 148612-17-3)
- 4-Amino-2-chloro-6-methylpyrimidine-5-carboxylic acid (CAS 1531671-00-7)
- 3-Amino-6-chloro-5-methylpyrazine-2-carboxylic acid (CAS 1555848-29-7)
Recommended Standards
- Methyl 4-chloro-6-methyl-1,3,5-triazine-2-carboxylate (CAS 1779495-09-8)
- Methyl 6-chloro-4-hydroxynicotinate (CAS 1781900-26-2)
- (6-Chloropyridazin-3-yl)glycine (CAS 17284-99-0)
- 5-Amino-2-chloro-4-hydroxybenzoic acid (CAS 1783628-13-6)
- N-(2-Dimethylaminoethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide (CAS 832114-11-1)
- 5-Fluoro-[2,3'-bipyridine]-5'-carboxamide (CAS 1346686-89-2)
- 4,9-Dimethoxy-5,8-methanonaphtho[2,3-c]furan-1,3(5H,8H)-dione (CAS 650616-59-4)
- 3,6-Bis(5-bromothiophen-2-yl)-2,5-bis(2-octyldodecanoyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione (CAS 1397261-39-0)
- Nintedanib Impurity 95 (CAS 16320-52-8)
- Methyl 2-(2-{[2-fluoro-5-(trifluoromethyl)phenyl]sulfamoyl}-4,5-dimethoxyphenyl)acetate (CAS 1023518-38-8)
- Ethyl 1-(iodomethyl)-2-oxabicyclo[2.2.2]octane-4-carboxylate (CAS 2459740-30-6)
- Ethyl 2-formyl-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-imidazole-4-carboxylate (CAS 1211532-71-6)
- 2-(4-Methylpyridin-2-yl)acetic acid hydrochloride (CAS 1609395-40-5)
- Semaglutide impurity 41 (CAS CATO-C4X-222641)
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