6-fluoroquinazoline-4-carboxylic acid CAS 1781315-63-6
| CAS No. | 1781315-63-6 |
| Molecular Formula | C9H15FN2O2 |
| Molecular Weight | 202.23 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-fluoroquinazoline-4-carboxylic acid (CAS 1781315-63-6), molecular formula C9H15FN2O2 and molecular weight 202.23 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to an amide group, a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, 6-fluoroquinazoline-4-carboxylic acid is typically white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 202.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-fluoroquinazoline-4-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C9H15FN2O2 |
| Molecular Weight | 202.23 g/mol |
| Appearance | White to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Related fluoroquinazoline Standards
- 7-fluoroquinazoline-4-carboxylic acid (CAS 1780977-86-7)
- 8-fluoroquinazoline-4-carboxylic acid (CAS 1781315-52-3)
- 6-fluoroquinazoline-2-carboxylic acid (CAS 1785337-73-6)
- 5-Fluoroquinazoline-2,4(1H,3H)-dione (CAS 192570-33-5)
- 8-Fluoroquinazoline-2,4(1H,3H)-dione (CAS 959236-96-5)
- 6-Fluoroquinazoline-2,4-diamine (CAS 119584-77-9)
- 7-Fluoroquinazoline-2,4-diamine (CAS 119584-78-0)
- 8-Fluoroquinazoline-2,4-diamine (CAS 119584-79-1)
Recommended Standards
- 2-(4-fluoro-1H-1,3-benzodiazol-1-yl)acetic acid (CAS 1785241-60-2)
- 7-fluoro-1-methyl-1H-indazole-4-carboxylic acid (CAS 1780632-73-6)
- 2H-Thiochromeno[7,8-b]furan-2-one (CAS 178625-88-2)
- (5-(4-Fluorophenyl)pyridin-3-yl)methanamine (CAS 177976-53-3)
- 4-Amino-6,7-dimethoxyquinoline-3-carbohydrazide (CAS 1330038-10-2)
- 2-((5-Methyl-1,3,4-thiadiazol-2-yl)thio)-N-((tetrahydrofuran-2-yl)methyl)acetamide (CAS 727688-79-1)
- (1R,5R,6R)-6-(trifluoromethyl)-2-azabicyclo[3.1.0]Hexane hydrochloride (CAS 1821803-66-0)
- 1-{2-[(2-Carboxyphenyl)amino]-2-oxoethyl}-1H-indole-2-carboxylic acid (CAS 1242928-26-2)
- 2-(Bicycloheptyl)dimethylchlorosilane (CAS 5089-28-1)
- 5-Cyclopropylisoxazol-4-amine (CAS 1080689-57-1)
- methyl (E)-2-(tert-butoxycarbonylamino)-3-tetrahydropyran-4-yl-prop-2-enoate (CAS 1361215-56-6)
- 1-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydroquinolin-2(1H)-one (CAS 1629612-36-7)
- Clopidogrel Impurity 113 (CAS 16694-46-5)
- Peptide Impurity 27 (CAS 1350456-68-6)
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