2-Fluoro-5-((trimethylsilyl)ethynyl)pyridine CAS 1782279-22-4
| CAS No. | 1782279-22-4 |
| Molecular Formula | C10H12FNSi |
| Molecular Weight | 193.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 2-Fluoro-5-((trimethylsilyl)ethynyl)pyridine is closely related to a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
CATO supplies 2-Fluoro-5-((trimethylsilyl)ethynyl)pyridine (CAS 1782279-22-4), a certified reference material (molecular formula C10H12FNSi, MW 193.29 g/mol) for analytical method development and quality control.
The molecular framework of 2-Fluoro-5-((trimethylsilyl)ethynyl)pyridine (C10H12FNSi) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H12FNSi |
| Molecular Weight | 193.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 2-Fluoro-4-((trimethylsilyl)ethynyl)pyridine (CAS 1378976-75-0)
- 2-fluoro-3-[2-(trimethylsilyl)ethynyl]pyridine (CAS 207602-10-6)
- 5-fluoro-2-[2-(trimethylsilyl)ethynyl]pyridine (CAS 884494-40-0)
- 6-Fluoro-3-(propan-2-yl)-1,2,3,4-tetrahydroquinoline (CAS 1017117-98-4)
- 4-(2-Fluoro-5-methylphenyl)piperidine (CAS 1019373-90-0)
- 3-(4-Fluoro-3-methylphenyl)piperidine (CAS 1044765-41-4)
- 3-(5-Fluoro-2-methylphenyl)piperidine (CAS 1044768-79-7)
- 3-(3-Fluoro-4-methylphenyl)piperidine (CAS 1044768-81-1)
Recommended Standards
- 3-(2-Cyclopentyl-1H-imidazol-1-yl)propan-1-amine (CAS 1779798-30-9)
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- n-Isopentyl-2-methoxyaniline (CAS 176536-14-4)
- 2-(3-Propyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazol-2-yl)ethan-1-amine (CAS 1784196-85-5)
- (S)-1-morpholinopropan-2-amine (CAS 878279-07-3)
- 2-(3-(Thiophen-2-yl)-1H-1,2,4-triazol-5-yl)phenol (CAS 165679-47-0)
- (S)-1-Acetylpyrrolidin-2-yl acetate (CAS 221911-75-7)
- 1-(4-Iodophenyl)naphthalene (CAS 1001337-35-4)
- Copper(1+), bis[1,2-ethenediylbis[diphenylphosphine]-P,P']-, chloride (CAS 102532-71-8)
- Olopatadine-d3 Hydrochloride (CAS 1331635-21-2)
- 5-((1H-pyrazol-1-yl)methyl)furan-2-carboxylic acid (CAS 386736-99-8)
- 2-(Naphthalene-2-sulfonylamino)butyric acid (CAS 145730-98-9)
- 2-((5-(2-Fluorophenyl)-1,3,4-oxadiazol-2-yl)thio)-N-(5-methylisoxazol-3-yl)acetamide (CAS 850937-08-5)
- Semaglutide impurity 64 (CAS CATO-C4X-222664)
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