4-Bromo-2,5-difluoro-3-methylbenzoic acid CAS 178444-98-9
| CAS No. | 178444-98-9 |
| Molecular Formula | C8H5BrF2O2 |
| Molecular Weight | 251.02 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO supplies 4-Bromo-2,5-difluoro-3-methylbenzoic acid (CAS 178444-98-9), a certified reference material (molecular formula C8H5BrF2O2, MW 251.02 g/mol) for analytical method development and quality control.
4-Bromo-2,5-difluoro-3-methylbenzoic acid (C8H5BrF2O2) contains a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/bromine substitution, an aromatic ring system. Halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 4-Bromo-2,5-difluoro-3-methylbenzoic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C8H5BrF2O2 |
| Molecular Weight | 251.02 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2007 |
| Halogen Content | F/Br-containing |
Related Bromo Standards
- 3-Bromo-4-(difluoromethyl)benzoic acid (CAS 1131615-04-7)
- Methyl 5-bromo-2,3-difluorobenzoate (CAS 1150163-69-1)
- 3-Bromo-4-(difluoromethoxy)benzaldehyde (CAS 1155878-02-6)
- 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one (CAS 1192815-24-9)
- Methyl 4-Bromo-2,5-difluorobenzoate (CAS 1193162-21-8)
- Methyl 3-bromo-4,5-difluorobenzoate (CAS 1244642-70-3)
- 3-Bromo-2-(difluoromethoxy)benzaldehyde (CAS 1249999-12-9)
- 2-(3-Bromo-2,6-difluorophenyl)acetic acid (CAS 1250443-19-6)
Recommended Standards
- 2-Bromo-5-(difluoromethyl)benzoic acid (CAS 1783329-70-3)
- 2-Bromo-4-(difluoromethyl)benzoic acid (CAS 1784852-57-8)
- 4-Bromo-3,5-difluorophenylacetic acid (CAS 1782832-99-8)
- 3-Bromo-2,6-difluoro-5-methoxybenzaldehyde (CAS 1785601-76-4)
- 2-Cyclopropyl-3-(4-iodo-1h-pyrazol-1-yl)-2-(methylamino)propanamide (CAS 1342606-62-5)
- rac-tert-butyl (1S,6R)-8,8-dimethyl-7-oxo-2-azabicyclo[4.2.0]octane-2-carboxylate (CAS 2059917-59-6)
- N-(3-aminopropyl)-4-fluoro-N-methylaniline (CAS 933737-13-4)
- 3-(4-Nitrophenyl)-5-(thiophen-2-yl)-1,2,4-oxadiazole (CAS 54608-96-7)
- 1-Benzyl-3-(5-{[(4-chlorophenyl)methyl]sulfanyl}-1,3,4-oxadiazol-2-yl)-1,2-dihydropyridin-2-one (CAS 242472-24-8)
- 3-(Trifluoromethyl)-4,5,6,7-tetrahydro-3H-pyrazolo[3,4-c]pyridine hydrochloride (CAS 733757-88-5)
- Methyl 3-(2-fluoro-4-methoxyphenyl)-2-propenoic Acid (CAS 852181-14-7)
- 2-((5-((Naphthalen-1-ylamino)methyl)-4-phenyl-4H-1,2,4-triazol-3-yl)thio)acetohydrazide (CAS 1071400-62-8)
- 2-Cyclopropylpyrazolo[1,5-a]pyrimidin-7-ol (CAS 1187875-92-8)
- 1-His-N-a-ethylidene Semaglutide (CAS CATO-C4X-2226252)
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