(3R,4S)-4-(3,5-difluoropyridin-4-yl)-2-oxopyrrolidine-3-carboxylic acid CAS 1784748-09-9
| CAS No. | 1784748-09-9 |
| Molecular Formula | C10H8F2N2O3 |
| Molecular Weight | 242.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), (3R,4S)-4-(3,5-difluoropyridin-4-yl)-2-oxopyrrolidine-3-carboxylic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
(3R,4S)-4-(3,5-difluoropyridin-4-yl)-2-oxopyrrolidine-3-carboxylic acid (CAS 1784748-09-9) is a high-purity analytical reference standard with the molecular formula C10H8F2N2O3 and a molecular weight of 242.18 g/mol.
The molecular framework of (3R,4S)-4-(3,5-difluoropyridin-4-yl)-2-oxopyrrolidine-3-carboxylic acid (C10H8F2N2O3) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C10H8F2N2O3 |
| Molecular Weight | 242.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1994 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 2 |
Recommended Standards
- 2-(Methylsulfonyl)-6-(trifluoromethyl)pyrimidin-4(3H)-one (CAS 1779983-09-3)
- 2-(2-Cyano-6-(difluoromethyl)-3-methoxypyridin-4-yl)acetic acid (CAS 1804421-58-6)
- 5-(3,3-Difluoroazetidin-1-yl)-2-nitrobenzaldehyde (CAS 1779120-06-7)
- 2-(6-Cyano-4-(difluoromethyl)-5-methoxypyridin-3-yl)acetic acid (CAS 1804421-71-3)
- 2,3-Difluoro-5-methoxy-benzoic acid (CAS 1262197-31-8)
- 3-(sec-Butyl)-5-((3-(4-fluorophenyl)-1-phenyl-1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one (CAS 623935-65-9)
- 7-Bromo-4-methylquinolin-2-amine (CAS 1895092-49-5)
- Creatine Phosphate Impurity 9 (CAS 71160-37-7)
- 1-[2-(3-Nitrophenyl)-2-oxoethyl]pyridinium iodide (CAS 317377-56-3)
- tert-butyl N-{[3-(hydroxymethyl)morpholin-3-yl]methyl}carbamate (CAS 1989659-21-3)
- D-chiro-Inositol (CAS 643-12-9)
- Methyl (2R,3S)-3-(4-bromophenyl)-2-methylbutanoate (CAS 2079925-26-9)
- Metaraminol Impurity 36 (CAS 1700-37-4)
- Semaglutide impurity 214 (CAS CATO-C4X-2226214)
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