Olaparib Impurity 22 CAS 179897-89-3
| CAS No. | 179897-89-3 |
| Molecular Formula | C7H3BrFN |
| Molecular Weight | 200.01 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Olaparib Impurity 22.
As a process- or degradation-related impurity, Olaparib Impurity 22 (CAS 179897-89-3, C7H3BrFN) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Olaparib Impurity 22 (C7H3BrFN) contains a nitrile group, fluorine/bromine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 6.0, corresponding to approximately 6 ring(s) or double-bond equivalent(s). With a molecular weight of 200.01 g/mol, it falls into the medium-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C7H3BrFN |
| Molecular Weight | 200.01 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 2008 |
| Halogen Content | F/Br-containing |
| Nitrogen Atoms | 1 |
Related Olaparib Standards
- Olaparib Impurity 86 (CAS 17159-16-9)
- Olaparib Impurity 32 (CAS CATO-C4X-113532)
- Olaparib Impurity 68 (CAS 77771-03-0)
- Olaparib Impurity 66 (CAS 40019-44-1)
- Olaparib Impurity 21 (CAS 54769-22-1)
- Olaparib Impurity 25 (CAS 57260-71-6)
- Olaparib Impurity 150 (CAS CATO-C4X-1135150)
- Olaparib Impurity 91 (CAS 547698-14-6)
Recommended Standards
- 4-Bromo-2-fluorophenylisocyanide (CAS 730964-93-9)
- 4-Bromo-2-fluorobenzonitrile (CAS 105942-08-3)
- 3-Bromo-4-fluorobenzonitrile (CAS 79630-23-2)
- 5,7-Dichloropyrido[4,3-d]pyrimidine (CAS 1029720-84-0)
- Cefdinir Impurity 86 (CAS 1884263-19-7)
- Ticagrelor Impurity 115 (CAS 1823431-32-8)
- Eldecalcitol Impurity 77 (CAS CATO-C4X-214077)
- 2-Methoxy-N-(3-(methylsulfonamido)phenyl)acetamide (CAS 1209746-63-3)
- 4-(2,2-Difluoroethoxy)-2-methylaniline (CAS 937602-96-5)
- 6,8-Dichloro-3-(furan-2-carbonyl)-2-phenyl-4H-chromen-4-one (CAS 673857-32-4)
- 2-Cyano-3-[1-(4-fluorophenyl)-2,5-dimethyl-1h-pyrrol-3-yl]prop-2-enoic acid (CAS 733030-69-8)
- 3,3-Di-(phthalimidomethyl)oxetane (CAS 198572-34-8)
- 5-Ethyl-1-methyl-1h-pyrazol-3-amine (CAS 1248011-02-0)
- Semaglutide Impurity 9 (CAS CATO-C4X-22269)
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