6-Methoxypyrimidin-2(1H)-one CAS 18002-25-0
| CAS No. | 18002-25-0 |
| Molecular Formula | C22H23N3O4S |
| Molecular Weight | 425.50 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 6-Methoxypyrimidin-2(1H)-one.
6-Methoxypyrimidin-2(1H)-one (CAS 18002-25-0), molecular formula C22H23N3O4S and molecular weight 425.50 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6-Methoxypyrimidin-2(1H)-one (C22H23N3O4S) is characterized by a flavonoid core, an amide group, a sulfone group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 6-Methoxypyrimidin-2(1H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C22H23N3O4S |
| Molecular Weight | 425.50 g/mol |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1962 |
| Nitrogen Atoms | 3 |
| Sulfur Atoms | 1 |
Related Methoxypyrimidin Standards
- 3-(2-methoxypyrimidin-5-yl)-N-(oxan-4-yl)imidazo[1,2-b]pyridazin-6-amine (CAS 1012345-09-3)
- N-(6-Methoxypyrimidin-4-yl)naphthalene-2-sulfonamide (CAS 1421584-94-2)
- (2-Methoxypyrimidin-5-yl)(4-(p-tolyl)piperazin-1-yl)methanone (CAS 1251624-19-7)
- N-(6-Methoxypyrimidin-4-yl)benzo[c][1,2,5]thiadiazole-5-carboxamide (CAS 1396851-41-4)
- N-(5-Methoxypyrimidin-2-yl)-N,2-dimethylquinazolin-4-amine (CAS 827031-81-2)
- (2-Methoxypyrimidin-5-yl)methyl 2-methoxypyrimidine-5-carboxylate (CAS 1707587-03-8)
- N-(5-Methoxypyrimidin-2-yl)-2-methylquinazolin-4-amine (CAS 827031-80-1)
- Bis((2-methoxypyrimidin-5-yl)methyl)amine (CAS 2089335-05-5)
Recommended Standards
- (+)-5-(1-(3,4-Dimethoxybenzoyl)-1,2,3,4-tetrahydroquinolin-6-yl)-6-methyl-3,6-dihydro-2H-1,3,4-thiadiazin-2-one (CAS 147527-31-9)
- (19E)-4-fluoro-17,17-dimethyl-1,5,8,13,15,22,27-heptaazatetracyclo[20.2.2.1¹⁰,¹⁴.0²,⁷]heptacosa-2,4,6,10,12,14(27),19-heptaen-9-one (CAS 2227259-31-4)
- N-(2-{[4-(Benzyloxy)phenyl]methanesulfonyl}-1-phenylethyl)-N-hydroxyformamide (CAS 1253527-86-4)
- 1-(2-Phenyl-4-tosyloxazol-5-yl)piperidine-4-carboxamide (CAS 823829-00-1)
- 2-{[3-cyano-4-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-2-yl]sulfanyl}-N-[(3,4-dichlorophenyl)methyl]acetamide (CAS 626227-67-6)
- (1R,2R)-1,2-Cyclohexanedimethanol (CAS 65376-05-8)
- 3-(3-(Methylthio)phenyl)-1H-pyrazol-5-amine (CAS 2169350-90-5)
- 4-Methyl-2-((2-methylcyclohexyl)amino)pentan-1-ol (CAS 1247472-83-8)
- (E)-1-{3-[(2-Chloro-6-fluorobenzyl)oxy]phenyl}-3-(4-fluoroanilino)-2-propen-1-one (CAS 478039-90-6)
- Ethyl 2-(5-cyano-2-methoxyphenyl)acetate (CAS 959958-23-7)
- Thioctic acid impurity 62 (CAS 93892-06-9)
- Methyl (S)-3,3,3-trifluoro-2-hydroxypropanoate (CAS 189060-64-8)
- tert-Butyl-dimethyl-(3-[7R-methyl-1R-(1R,4R,5-trimethyl-hex-2-enyl)-octahydro-inden-4-ylidenemethyl]-2,2-dioxo-2,3,4,5,6,7-hexahydro-1H-2l6-benzo[c]thiophen-5S-yloxy)-silane (CAS 170081-43-3)
- D-Pro37-Tirzepatide (CAS CATO-CPTD788902)
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